Thyrotropin level and cognitive performance: Baseline results from the ELSA-Brasil Study

Psychoneuroendocrinology
Claudia SzlejfIsabela M Benseñor

Abstract

The role of subtle thyroid alterations, such as subclinical thyroid disease and low/high serum thyrotropin (TSH) within the normal range, on cognitive decline is controversial. The aim of this study was to evaluate the association of serum TSH and subclinical thyroid dysfunction with performance on cognitive tests in a large sample of Brazilian middle-aged adults without overt thyroid disease. In this cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health, we excluded individuals aged 65 years and older, with overt thyroid dysfunction, prevalent stroke, in use of medications that affect thyroid function or that indicate neurologic diseases, and from Asian or indigenous ethnicity. Thyroid status was assessed by serum TSH and free thyroxine (only when the TSH was altered). Individuals were divided according to TSH tertiles and classified according to thyroid function as euthyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism. Cognition was evaluated using delayed word recall test, semantic verbal fluency test, and trail making test version B. The associations of cognitive tests performance with TSH tertiles (using the middle tertile as reference) and thyroid function were investigated using ...Continue Reading

Citations

Apr 6, 2019·Journal of Cancer Survivorship : Research and Practice·Omar SaeedAnna M Sawka
Nov 14, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Juliana Nery de Souza-TalaricoIsabela J M Bensenõr
Apr 11, 2019·Frontiers in Endocrinology·Valeria CalsolaroFabio Monzani
Jan 5, 2019·Journal of the Endocrine Society·Valeria CalsolaroFabio Monzani
Feb 21, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·I M Bensenor
May 11, 2021·Journal of Alzheimer's Disease : JAD·Claudia SzlejfIsabela Martins Benseñor

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