PMID: 2497681Jan 1, 1989Paper

Thyrotropin-releasing hormone and central nervous system trauma

Annals of the New York Academy of Sciences
A I FadenT K McIntosh

Abstract

TRH and TRH analogues improve physiological function, survival, and neurological outcome in a variety of models of CNS trauma, including impact spinal cord injury in cats and rats, fluid-percussion-induced brain injury in rats, and compression-induced brain injury in cats. The mechanism by which TRH improves such functions may relate to its ability to improve blood flow and metabolism in the region of injury. Beneficial effects on blood flow may possibly relate to antagonism of the physiological effects of endogenous opioids, leukotrienes, or platelet-activating factor.

References

May 1, 1988·The American Journal of Physiology·T K McIntoshA I Faden
Oct 29, 1981·The New England Journal of Medicine·A I FadenJ W Holaday

❮ Previous
Next ❯

Citations

May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A M Lam
Jul 12, 2002·Bioorganic & Medicinal Chemistry·K R C PrakashAlan I Faden
Aug 7, 2002·The Journal of Pharmacy and Pharmacology·Jiaxiang WuNicholas Bodor
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Apr 18, 2020·Growth Factors·María Del Carmen Díaz-GalindoJ Luis Quintanar
Sep 24, 2005·Annals of the New York Academy of Sciences·Alan I FadenIbolja Cernak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.