PMID: 2125519Oct 15, 1990Paper

Thyrotropin-releasing hormone causes direct excitation of dorsal vagal and solitary tract neurones in rat brainstem slices

Brain Research
M RaggenbassJ J Dreifuss

Abstract

The effect of thyrotropin-releasing hormone (TRH) on neurones in the dorsal motor nucleus of the vagus and the nucleus of the solitary tract was studied using extracellular single-unit recordings from brainstem slices of the rat. About one third of vagal neurones were excited by TRH. The remaining neurones were unaffected. The lowest effective peptide concentration was around 10 nM and a half maximal effect was achieved at about 100 nM. The action of TRH persisted in a low-calcium, high-magnesium solution which blocks synaptic transmission. The biologically inactive compound, TRH-free acid, was without effect. In the nucleus of the solitary tract, one fourth of the neurones were excited by TRH; none were inhibited by this peptide. Part of the vagal TRH-responsive neurones were also excited by oxytocin and some of the solitary tract neurones sensitive to TRH also responded to vasopressin. We conclude that a fraction of neurones located in the dorsal motor nucleus of the vagus and the nucleus of the solitary tract possess functional TRH receptors. TRH may thus act as a neurotransmitter or neuromodulator in the dorsal brainstem and may participate in the regulation of autonomic functions.

References

Sep 23, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T Takahashi
Feb 1, 1989·Journal of Medicinal Chemistry·M ManningW H Sawyer
Nov 1, 1988·Journal of the Autonomic Nervous System·M J McCannR C Rogers
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M RaggenbassJ J Dreifuss
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Mar 15, 1985·The Journal of Comparative Neurology·M Kalia, K Fuxe
Jul 19, 1974·Science·A Winokur, R D Utiger
Aug 1, 1974·Endocrinology·C OliverJ C Porter

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Citations

Dec 1, 1992·Brain Research Bulletin·M IwaseI Homma
May 1, 1997·Journal of Physiology, Paris·K A KovácsG Mózsik
Oct 22, 2002·The Journal of Comparative Neurology·María Del Carmen De AndrésMaría José González
Nov 1, 2002·The Journal of Comparative Neurology·Oscar TeijidoRamón Anadón
Jul 19, 2002·The Journal of Comparative Neurology·María Luz DíazRamón Anadón
Mar 1, 1994·Scandinavian Journal of Gastroenterology·T OkumuraM Namiki
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean
Nov 24, 1999·The American Journal of Physiology·D MutoloT Pantaleo

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