PMID: 2498419Mar 1, 1989Paper

Thyrotropin-releasing hormone: effects on identified neurons of the dorsal vagal complex

Journal of the Autonomic Nervous System
M J McCannR C Rogers

Abstract

Previous reports have demonstrated that intraventricular administration of thyrotropin-releasing hormone (TRH) markedly elevates parasympathetic efferent activity. The following study determined if this response could be attributed to an effect of TRH on the neurons in the dorsal motor nucleus of the vagus (DMN) and/or the nucleus tractus solitarius (NTS), the nuclei that comprise the dorsal vagal complex (DVC). Individual DMN or NTS units were identified electrophysiologically by using stimulating electrodes placed on the cervical vagus. Alterations in firing rate of identified cells in response to pressure injection of TRH (10-40 fmol in 10-40 pl) or equal volumes of artificial cerebrospinal fluid (ACSF) were monitored. Of the DMN cells that were responsive to TRH, all were excited, whereas all responsive NTS cells were inhibited by this peptide. TRH was characterized as potent and had long-lasting effects on cells in DMN and NTS. The action of TRH on both nuclei in the dorsal vagal complex may explain the powerful effects of this peptide on vagally mediated functions.

References

Jul 1, 1979·The Journal of Comparative Neurology·S NosakaK Yasunaga
Jul 1, 1987·Neuropharmacology·J L BarkerJ F MacDonald
Jan 1, 1987·Chronobiology International·Y Tache
Dec 1, 1985·Journal of the Autonomic Nervous System·R C Rogers, G E Hermann
Jul 11, 1980·European Journal of Pharmacology·M C Koss

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Citations

Jan 1, 1996·Neuroscience and Biobehavioral Reviews·R C RogersG E Hermann
Oct 1, 1991·Regulatory Peptides·M M Heitkemper, E F Bond
Dec 1, 1992·Brain Research Bulletin·M IwaseI Homma
Feb 9, 2002·European Journal of Pharmacology·Sridhar VaranasiRobert L Stephens
Nov 25, 2000·Peptides·V Martinez, Y Taché
Jan 1, 1990·Annals of the New York Academy of Sciences·Y Taché, H Yang
Dec 14, 2011·The Journal of Physiology·Edouard ViardGerlinda E Hermann
Jul 19, 2002·The Journal of Comparative Neurology·María Luz DíazRamón Anadón
Nov 1, 2002·The Journal of Comparative Neurology·Oscar TeijidoRamón Anadón
Aug 5, 2008·Journal of Chemical Neuroanatomy·Jesús M LópezAgustín González
Aug 10, 2010·Brain Research·Maria J BarnesGerlinda E Hermann
Oct 16, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M Swartz, G M Holmes
Nov 1, 1996·Psychosomatic Medicine·H Weiner
Jun 30, 2005·American Journal of Physiology. Endocrinology and Metabolism·Pu-Qing Yuan, Hong Yang
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Dec 7, 2006·Annals of the New York Academy of Sciences·Ioannis KyrouConstantine Tsigos
Apr 17, 2001·Journal of Neurosurgery·M W TullousP A Mancuso
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean
Aug 13, 1999·The American Journal of Physiology·Y LiC Owyang
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·R A Travagli, R C Rogers

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