Thyrotropin-releasing hormone immunoreactivity in the gastrointestinal tract of man

The Journal of Clinical Endocrinology and Metabolism
L O DolvaT Sand

Abstract

TRH inhibits gastric secretion, gastric motility, and pancreatic enzyme secretion in man. We measured TRH immunoreactivity (TRH-IR) in mucosal and transmural biopsies from different parts of the stomach, pylorus, duodenum, and pancreas in patients undergoing surgery or gastroscopy. TRH-IR was found in pancreas (range, 1.64-3.27 pg TRH/mg protein) and in mucosa of the fundus (13.3 +/- 2.0 pg TRH/mg protein), antrum (22.5 +/- 4.5 pg TRH/mg protein), and duodenum (35.5 +/- 6.4 mg TRH/mg protein). Low levels of TRH-IR were found in transmural biopsies from fundus, antrum, and pylorus (range, 0.45-0.87 pg TRH/mg protein). Chromatography of gastrointestinal tissue extracts on a cation exchange column resulted in two different TRH-IR peaks, one eluted at pH 3.5 and the other eluted at pH 7.4. The peak at pH 7.4 corresponded to synthetic TRH. The presence and the action of TRH in human gut indicate a physiological role of TRH in the gastrointestinal tract in man.

Citations

Jan 1, 1985·Acta neurochirurgica·C R Pickardt, P C Scriba
May 1, 1997·Journal of Physiology, Paris·K A KovácsG Mózsik
Jan 1, 1989·Annals of the New York Academy of Sciences·T HökfeltJ Freedman
Jul 1, 1990·The Anatomical Record·P S MandrekarN A Sheth
Jun 1, 1989·Alcoholism, Clinical and Experimental Research·H KnutsenJ Mørland
Jun 1, 1985·Scandinavian Journal of Gastroenterology·A S Suhonen-MalmT Larmi

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