PMID: 2497684Jan 1, 1989Paper

Thyrotropin-releasing hormone in ALS. Are the results of clinical studies inconsistent?

Annals of the New York Academy of Sciences
M H Brooke

Abstract

The results of the various studies and an analysis of the methodology are presented in TABLE 1. As can be seen, there was no "perfect" study. In five of the studies enough information was presented with regard to the measurements and the behavior of control patients that a statistical analysis could be performed. Three of the studies showed a transient, statistically significant effect in at least some muscles. The two studies that demonstrated no such effect both used TRH in very small doses. It therefore seems reasonable to conclude that the effect of TRH in ALS is a definite, acute, and transient response. The cause of this response, however, has not been documented, and whether it is associated with an effect of the drug on the disease process remains to be seen.

References

Aug 14, 1986·Biochemical and Biophysical Research Communications·E F HawkinsW K Engel
Jul 1, 1986·Neurology·P L AndresT L Munsat
Oct 1, 1974·Canadian Journal of Physiology and Pharmacology·A DupontA V Schally
Dec 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·K ImotoH Nishitani
May 1, 1981·Muscle & Nerve·M H BrookeR J Pellegrino

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Citations

Apr 20, 2012·The Cochrane Database of Systematic Reviews·Renske I WadmanAlexander F J E Vrancken

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