Thyrotropin-releasing hormone in critical illness: from a dopamine-dependent test to a strategy for increasing low serum triiodothyronine, prolactin, and growth hormone concentrations

Critical Care Medicine
Greet Van den BergheP Lauwers

Abstract

The aim of this study was to examine the effect of dopamine infusion on the thyrotropin (TSH), thyroid hormone, prolactin, and growth hormone responses to thyrotropin-releasing hormone (TRH) in critically ill patients. Prospective, randomized, controlled, open-labeled clinical study. The intensive care unit, University Hospital Gasthuisberg, Leuven, over a 1-month period. In 15 critically ill patients receiving dopamine treatment (5 micrograms/kg/min) for a mean of 43.3 +/- 1.2 (SEM) hrs after trauma or cardiac surgery, we studied the TSH, thyroid hormone, prolactin, and growth hormone responses to the administration of two consecutive intravenous TRH boluses of 200 micrograms, with a 6-hr interval. The dopamine infusion was continued in the control group and discontinued in the study group. Serum concentrations of TSH, prolactin, and growth hormone were measured before and 20, 40, 60, and 120 mins after TRH administration. Serum concentrations of thyroxine (T4), triiodothyronine (T3), reverse T3, and thyroid hormone binding globulin were determined before and 120 mins after each TRH injection. There was a > 100-fold interindividual variation in the baseline TSH concentration and in the TSH peak value after TRH administration. ...Continue Reading

References

Feb 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K K TalwarG K Rastogi
Jun 11, 1979·Life Sciences·G R Van LoonM J Sole
Mar 1, 1975·The Journal of Clinical Endocrinology and Metabolism·K MaedaH Imura
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·T van der PollH P Sauerwein
Aug 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J FaberI W Jensen
Feb 28, 1985·The New England Journal of Medicine·R E WehmannG W Santos
Oct 3, 1974·The New England Journal of Medicine·L I Goldberg
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·P J Snyder, R D Utiger
Nov 1, 1984·Archives internationales de physiologie et de biochimie·V D'OrioR Marcelle
Jan 21, 1982·The New England Journal of Medicine·I M Jackson
Dec 1, 1982·Acta Endocrinologica·H VierhapperG Kleinberger
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·V BacciT B Kaplan
May 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E HeinenH L Krüskemper
Dec 1, 1994·Clinical Endocrinology·G Van den BergheP Lauwers

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Citations

Dec 24, 1997·Acta Paediatrica. Supplement·I Berczi
Sep 1, 1996·Critical Care Medicine·G Van den Berghe, F de Zegher
Oct 19, 2002·Current Opinion in Critical Care·John A Kellum, Michael R Pinsky
Oct 4, 2006·Current Opinion in Anaesthesiology·G Van den Berghe
Jul 21, 1998·Annals of the New York Academy of Sciences·I Berczi
Nov 18, 2005·Current Opinion in Critical Care·John A KellumClaudio Ronco

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