PMID: 7540012Feb 1, 1995Paper

Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites

Pediatric Neurology
Y TakeuchiT Sawada

Abstract

The efficacy of thyrotropin-releasing hormone in children with intractable epilepsy was investigated and changes in cerebrospinal fluid monoamine metabolites were analyzed. The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone. Thyrotropin-releasing hormone-tartrate was administered for 4 weeks. Before and after the thyrotropin-releasing hormone administration, cerebrospinal fluid was collected and analyzed for 5-hydroxyindoleacetic acid, kynurenine, homovanillic acid, and 3-methoxy-4-hydroxyphenyl glycol. The patients were classified into 3 groups, based on seizure frequency and electroencephalographic effects: cessation of seizures and seizure discharges (very effective; group A), reduction of seizures and/or seizure discharges (effective; group B), and no changes in frequency of seizures or discharges (not effective; group C). There were 6 patients in group A, 3 in group B, and 9 in group C. There were no significant differences in monoamine metabolites before and after the thyrotropin-releasing hormone therapy. A trial of thyrotropin-releasing hormone for the treatment of intractable epilepsy is ...Continue Reading

References

Apr 1, 1990·Experimental Neurology·K YamashitaS Otsuki
Jul 1, 1994·Journal of Child Neurology·Y TakeuchiT Sawada

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Citations

Jan 30, 2002·Pediatric Neurology·Michael J Kubek, Bhuwan P Garg
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Oct 25, 2011·Expert Opinion on Therapeutic Patents·Kailas S KhomaneArvind K Bansal
Jul 12, 2012·Molecular Pharmaceutics·Kailas S KhomaneArvind K Bansal

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