Thyrotropin-releasing hormone increased heat production without the involvement of corticotropin-releasing factor in neonatal chicks

Pharmacology, Biochemistry, and Behavior
Tetsuya TachibanaMitsuhiro Furuse

Abstract

Thyrotropin-releasing hormone (TRH) is a hypothalamic signal in the hypothalamic-pituitary-thyroid (HPT) axis, and is well known as a hyperthermic hormone in the brain of chicks. The thermogenetic effect leads to the hypothesis that central TRH increases heat production (HP) in chicks. The purpose of the present study was to clarify whether central TRH affects HP of neonatal chicks, and if such an effect is mediated by corticotropin-releasing factor (CRF) since the thermogenetic effect of TRH is mediated by CRF. Intracerebroventricular (ICV) injection of TRH (14 and 55 nmol) dose-dependently increased oxygen consumption, carbon dioxide production and HP, and a similar effect was also observed with CRF (2.1 and 21 pmol). The TRH-induced increase in HP could not be attenuated by astressin, a CRF receptor antagonist, while the effect of CRF was completely diminished by astressin. The present study demonstrates that central TRH increases HP in chicks but the effect was not related to CRF.

Citations

Dec 23, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ahmad Mujahid
Sep 13, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ahmad Mujahid, Mitsuhiro Furuse
Jun 30, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tetsuya TachibanaMitsuhiro Furuse
May 1, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tetsuya TachibanaMitsuhiro Furuse
Feb 13, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Tetsuya TachibanaMitsuhiro Furuse
Mar 20, 2019·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Betty R McConnElizabeth R Gilbert
May 22, 2021·Journal of Thermal Biology·Yoshimitsu OuchiTakashi Bungo

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