PMID: 6170395Oct 1, 1981Paper

Thyrotropin releasing hormone potentiates the effects of imipramine on brain serotonergic system

Brain Research Bulletin
R B RastogiY D Lapierre

Abstract

Daily administration of thyrotropin-releasing hormone (TRH) (20 mg/kg) for 10 days in 2 equally divided doses increased 5-hydroxytryptamine and/or 5-hydroxyindoleacetic acid levels in certain brain areas. Chronic imipramine treatment (10 mg/kg) for 10 days significantly decreased the levels of brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. When TRH was administered concurrently with imipramine (10 mg/kg), this neuropeptide significantly potentiated the effects of imipramine on lowering of endogenous levels of 5-hydroxytryptamine (striatum, hypothalamus) and 5-hydroxyindoleacetic acid (striatum, midbrain, pons-medulla). Our data provide a possible neurochemical basis for the reported potentiation of tricyclic antidepressant action by TRH.

References

Feb 15, 1976·Biochemical Pharmacology·N P Plotnikoff, A J Kastin
Jan 1, 1977·Annual Review of Physiology·W ValeM Brown
Sep 1, 1977·Acta Psychiatrica Scandinavica·H P VogelA Poppenberg
Oct 1, 1976·The American Journal of Psychiatry·F W FurlongM F Beeching
Nov 1, 1972·European Journal of Pharmacology·J Bruinvels

❮ Previous
Next ❯

Citations

Nov 1, 1984·Neuropeptides·R J Niesink, J M van Ree
Oct 1, 2002·Acta Neuropsychiatrica·Marta KuberaMichael Maes
Jan 1, 1988·Journal of Receptor Research·M R PranzatelliS Markush

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.