PMID: 6405395Mar 1, 1983Paper

Thyrotropin-releasing hormone reverses the hypotension and bradycardia produced by leukotriene D4 in unanesthetized guinea pigs

Prostaglandins, Leukotrienes, and Medicine
W E LuxA I Faden

Abstract

We have utilized an unanesthetized guinea pig model to study the cardiovascular effects of leukotriene D4 (LTD4), a compound implicated in slow reacting substance of anaphylaxis (SRS-A). Intravenous (IV) administration of LTD4 at 5 micrograms/kg produced profound hypotension, bradycardia, hypoxia and acidosis. The hypotension and bradycardia were rapidly and completely reversed by IV thyrotropin-releasing hormone (TRH) at a dose of 2 mg/kg. In contrast, TRH treatment had no effect on the hypoxia or acidosis induced by LTD4. These data provide a potential physiological link between two distinct classes of endogenous substances and may have implications for the therapy of anaphylactic shock.

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Citations

Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·S CeylanA Ozoran
Jan 1, 1990·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·D ZhengD Y Hu
May 1, 1984·Prostaglandins·G Feuerstein
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A KepplerS Hammarström
Sep 1, 1992·The American Review of Respiratory Disease·Y TanigawaraR Hori
Jun 1, 1985·Journal of Autonomic Pharmacology·G Feuerstein
Apr 1, 1985·Klinische Wochenschrift·M GoerigG Schettler
May 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H Bitterman, A M Lefer

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