Thyrotropin-releasing hormone (TRH) evokes chloride secretion via cholinergic pathways in the guinea-pig ileum

European Journal of Pharmacology
H V Carey, H J Cooke

Abstract

The effect of thyrotropin-releasing hormone (TRH) on ion transport in the guinea-pig ileum was investigated in flux chambers. TRH evoked a concentration-dependent increase in short-circuit current that was due to active anion secretion. The response to TRH was prevented by tetrodotoxin and nearly abolished by atropine, but was not affected by mecamylamine. The results suggest that TRH plays a role as a neuromodulator or neurotransmitter that influences secretory processes by directly or indirectly activating cholinergic motor neurons.

References

Nov 1, 1985·The Journal of Clinical Investigation·A WeymerK Dharmsathaphorn
May 20, 1985·European Journal of Pharmacology·H J Cooke, H V Carey
Mar 1, 1983·The Journal of Clinical Endocrinology and Metabolism·L O DolvaT Sand
Sep 1, 1982·Scandinavian Journal of Gastroenterology·L O DolvaE Schrumpf

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Citations

Oct 29, 1991·European Journal of Pharmacology·D H ZafirovJ D Wood

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