PMID: 6412572Sep 1, 1983Paper

Thyrotropin-releasing hormone (TRH) in abstinent alcoholic men

The American Journal of Psychiatry
P T LoosenA Tipermas

Abstract

Chronic alcoholics who had been abstinent from alcohol for more than 2 years were evaluated with the thyrotropin-releasing hormone (TRH) test. The findings suggest the following profound disturbances in the hypothalamic-pituitary-thyroid axis: 1) a "euthyroid sick syndrome," evidenced by low levels of triiodothyronine (T3), high levels of reverse T3, and normal levels of thyroxine (T4) (this syndrome implies a decreased 5'-deiodination of T4 to T3 and of reverse T3 to its lesser iodinated metabolites), 2) an increased binding capacity for thyroid hormones, evidenced by a decreased T3-uptake value and an increased level of T4-binding globulin, and 3) thyroid-stimulating hormone (TSH) blunting in 31% of patients. Paradoxically, there was a positive correlation between basal T4 and delta max TSH in subjects with blunted TSH, but baseline TSH levels were reduced in subjects with and without blunted TSH.

Citations

Jul 24, 2013·BioMed Research International·Hsiang Cheng ChiKwang-Huei Lin
May 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·C ReistE M Demet
May 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·L R NoonanG A Mason
Dec 1, 1992·The Australian and New Zealand Journal of Psychiatry·J D Sellman, P R Joyce
Jun 1, 1985·The Australian and New Zealand Journal of Psychiatry·P R Joyce
Oct 1, 1997·Addiction Biology·T D GeraciotiP E Keck
Jul 21, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Saliha OzsoySeher Sofuoglu

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