PMID: 6402874Mar 1, 1983Paper

Thyroxine and triiodothyronine levels in Snell mice

Acta Endocrinologica
S van Buul-OffersW Schopman

Abstract

Since no data are available concerning thyroid hormone levels in Snell dwarf mice from birth on, a cross-sectional study was performed of L-thyroxine (T4) and L-triiodothyronine (T3) levels in blood or serum as a function of age of several litters, starting at birth. In normal Snell mice T4 levels in blood and serum are changing with age. T4 increases during the first 2 weeks of age and declines thereafter, until adult levels of about 50 nmol/l are reached at 21 days of age. Serum T3 values are in the range of 2-3 nmol/l. They do not show such an age-related pattern. From birth on in each litter there was a clear separation between animals with low T4 levels in blood and the others. This separation was possible at all subsequent days until 9 days of age, when dwarfs can be recognized by eye. Above that age the low T4 values were associated with dwarfism. This suggests that dwarfs are hypothyroid already at birth. Serum T3 in dwarfs falls below the normal range only after 4 weeks of age, resulting in a lower T4/T3 ratio than normal. The half life time of exogenous T4 in serum of dwarfs is in the range of 13-18 h and not different from normal. For T3 t1/2 is 9.5-11.1 h. Dwarf mice become euthyroid by treatment with 0.1 microgram ...Continue Reading

Citations

Jan 1, 1986·Anatomy and Embryology·D B Wilson, D P Wyatt
Oct 1, 1990·Physiology & Behavior·R Bouchon, P Ropartz
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Roberto RocchiPatrizio Caturegli
Nov 19, 2013·Brain, Behavior, and Immunity·Anne-Laure SchangBobbi Fleiss
Jun 12, 2002·The American Journal of Pathology·Olena JacenkoZhuliang Tao

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