PMID: 2505856Sep 15, 1989Paper

Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats

Biochimica Et Biophysica Acta
L SavuE A Nunez

Abstract

We present evidence based on equilibrium and non-equilibrium binding studies, as well as on immunological techniques, that of the two rat specific thyroid-hormone-binding proteins, i.e., thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA), TBG but not TBPA is regulated by the thyroid hormones (TH). Hypothyroidism, induced from the day of birth by daily treatment with propylthiouracil (PTU-rats), leads to dramatic and sustained increases of the TH-binding abilities of the sera measured at equilibrium, whereas hyperthyroidism, induced by treatment with thyroxine (T4-rats), leads to the decrease of these abilities. Polyacrylamide gel electrophoresis and isoelectrofocalisation of radioiodinated T4-labelled sera, together with immunoassay of TBPA, demonstrate that both effects are due to TBG, the levels of which rise in PTU-rats and decline in T4-rats, while TBPA levels do not respond to either depletion or excess of the thyroid hormones. TBG rather than TBPA appears as the key thyroid-hormone-binding protein of the rat, inasmuch as it alone expresses a regulatory function of the thyroid hormones at protein synthesis level.

References

Jan 1, 1976·Endocrinology·R L Sutherland, M R Brandon
Nov 13, 1987·Biochemical and Biophysical Research Communications·L SavuE A Nunez
Feb 27, 1989·FEBS Letters·R VranckxE A Nunez
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
May 1, 1962·Endocrinology·L S FARERJ E RALL
May 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Charles G MullighanCheryl L Willman

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Citations

Jan 17, 2012·Proteomics·Elisabetta GianazzaIngrid Miller
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Oct 10, 2009·International Journal of Toxicology·J M HedgeK M Crofton
Mar 17, 2007·Critical Reviews in Toxicology·R Thomas ZoellerRochelle W Tyl
Nov 1, 1994·Endocrine Research·M H Lu, R R Anderson
May 1, 1993·Journal of Endocrinological Investigation·L Bartalena
Jul 26, 1991·Biochimica Et Biophysica Acta·L SavuI L Flink

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