PMID: 8592639Sep 29, 1995Paper

Thyroxine reduces the production rate of BrdU-labeled cells in the ventricular zone of the adult canary brain

Neuroscience Letters
O Arai, N Saito

Abstract

When the canary reaches adulthood, neuron production continues in the lateral ventricular zone (VZ) of the forebrain. The effect of thyroxine injection on the cell production rate in the VZ during adulthood was studied immunohistochemically using bromodeoxyuridine (BrdU). The rate of occurrence of BrdU-labeled cells was reduced by thyroxine injection (1 mg/body). Hyperthyroidism usually promotes increased mitotic activity, but in the present study this was not the case. The decrease in the number of BrdU-labeled cells in the VZ appears to have resulted from premature termination of cell proliferation due to early initiation of cell differentiation. Our results suggest that the production rate of cells in the VZ of the adult canary changes seasonally, decreasing in the summer when the plasma level of thyroxine increases.

References

May 22, 1989·The Journal of Comparative Neurology·J F Goldberg, E D Pollack
Sep 1, 1989·Brain Research. Developmental Brain Research·E J Nordeen, K W Nordeen
Sep 22, 1988·Nature·A Alvarez-Buylla, F Nottebohm
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Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·J KirnF Nottebohm
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·S RasikaA Alvarez-Buylla

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Citations

Feb 25, 1998·Behavioural Brain Research·S N PatelJ R Krebs
Aug 18, 2004·Annals of the New York Academy of Sciences·Linda Wilbrecht, John R Kirn
May 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nazia KhurshidSoumya Iyengar

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