Thyroxine signal transduction in liver cells involves phospholipase C and phospholipase D activation. Genomic independent action of thyroid hormone

BMC Cell Biology
N S KavokN A Babenko

Abstract

Numerous investigations demonstrate a novel role of thyroid hormone as a modulator of signal transduction. Protein kinase C (PKC) is critical to the mechanism by which thyroid hormones potentiate both the antiviral and immunomodulatory actions of IFNgamma in different cells and regulate the exchange of signalling phospholipids in hepatocytes. Because nothing is known about accumulation of PKC modulator - diacylglycerol in cells treated with T4, we examined the nongenomic effect of thyroid hormones on DAG formation and phospholipase activation in liver cells. The results obtained provide the first demonstration of phospholipase C, phospholipase D and protein kinase C nongenomic activation and diacylglycerol (DAG) accumulation by L-T4 in liver cells. The experiments were performed in either the [14C]CH3COOH-labeled rat liver slices or isolated hepatocytes pre-labeled by [14C]oleic acid. L-T4 activates the DAG production in a concentration- and time-dependent manner. DAG formation in stimulated cells is biphasic and short-lived event: there is an initial, rapid rise in DAG concentration and then a slower accumulation that can be sustained for a few minutes. The early phase of L-T4 generated DAG only is accompanied by phosphatidyli...Continue Reading

References

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Citations

Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Ralf Lösel, Martin Wehling
Jul 5, 2003·Physiological Reviews·Ralf M LoselMartin Wehling
Jan 26, 2005·Virchows Archiv : an International Journal of Pathology·Li Wen HuMaria Luiza Morais Barreto-Chaves
Jan 28, 2006·Virchows Archiv : an International Journal of Pathology·Luana Anjos-RamosMaria Luiza Morais Barreto-Chaves
Apr 25, 2009·IUBMB Life·Celine J Guigon, Sheue-yann Cheng
Apr 1, 2017·International Journal of Molecular Sciences·Fabrizio DamianoLuisa Siculella
Jan 9, 2013·The Journal of Endocrinology·Aline CordeiroCarmen Cabanelas Pazos-Moura
Jul 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Paolo De VitoPaul J Davis
Nov 16, 2012·Journal of Neuroscience Research·Hong-Mei ZhangMin Luo
Jan 11, 2016·Acta Physiologica·D GnocchiP Parini
Aug 10, 2011·Journal of Cellular Physiology·Gabriele V GnoniLuisa Siculella
Jan 5, 2017·Hormones & Cancer·Marina Inés FlaminiAngel Matías Sanchez
Jun 14, 2020·International Journal of Molecular Sciences·Marco GiammancoItalia Di Liegro
Jun 3, 2021·Cancers·Gabriella SchieraItalia Di Liegro
May 30, 2006·Peptides·M S Carneiro-RamosM L M Barreto-Chaves
Mar 30, 2010·The International Journal of Biochemistry & Cell Biology·Danusa MenegazFátima Regina Mena Barreto Silva

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Methods Mentioned

BETA
nuclear translocation

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