THz and mm-Wave Sensing of Corneal Tissue Water Content: Electromagnetic Modeling and Analysis

IEEE Transactions on Terahertz Science and Technology
Zachary D TaylorWarren S Grundfest

Abstract

Terahertz (THz) spectral properties of human cornea are explored as a function of central corneal thickness (CCT) and corneal water content, and the clinical utility of THz-based corneal water content sensing is discussed. Three candidate corneal tissue water content (CTWC) perturbations, based on corneal physiology, are investigated that affect the axial water distribution and total thickness. The THz frequency reflectivity properties of the three CTWC perturbations were simulated and explored with varying system center frequency and bandwidths (Q-factors). The modeling showed that at effective optical path lengths on the order of a wavelength the cornea presents a lossy etalon bordered by air at the anterior and the aqueous humor at the posterior. The simulated standing wave peak-to-valley ratio is pronounced at lower frequencies and its effect on acquired data can be modulated by adjusting the bandwidth of the sensing system. These observations are supported with experimental spectroscopic data. The results suggest that a priori knowledge of corneal thickness can be utilized for accurate assessments of corneal tissue water content. The physiologic variation of corneal thickness with respect to the wavelengths spanned by the ...Continue Reading

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Jul 15, 2015·IEEE Transactions on Terahertz Science and Technology·Zachary D TaylorWarren S Grundfest

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Citations

Oct 7, 2016·Drug Delivery and Translational Research·Raghu Raj Singh ThakurRyan F Donnelly
Feb 1, 2017·IEEE Transactions on Bio-medical Engineering·Neha BajwaZachary D Taylor
Nov 22, 2019·Journal of Zhejiang University. Science. B·Bin ZhangHua-Yong Yang
Jan 20, 2017·Biomedical Optics Express·Neha BajwaZachary D Taylor
Apr 29, 2020·Biomedical Optics Express·Jiali YaoYan Wang
Feb 11, 2021·Eye and Vision·Hormoz AbdshahzadehFarhad Hafezi
Jan 30, 2021·Scientific Reports·Yu-Chi LiuJodhbir S Mehta
Jun 10, 2021·Journal of Biophotonics·Lin KeYu-Chi Liu

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