Tiam1 is associated with hepatocellular carcinoma metastasis

International Journal of Cancer. Journal International Du Cancer
Jing HuangLonghua Chen

Abstract

We have previously demonstrated that overexpression of T lymphoma invasion and metastasis 1 (Tiam1) is correlated with poor prognosis in patients with hepatocellular carcinoma (HCC). In this study, we tried to further investigate the potential roles of Tiam1 in the progression of HCC in a larger set of samples. By detecting Tiam1 expression in 213 HCC patients, we observed that Tiam1 had a higher probability of being overexpressed in HCC patients with metastasis than those without metastasis (68.3% vs. 52.7%, p = 0.036). In addition, the cell line with high metastatic potential expressed more Tiam1 than did the cell line with low metastatic potential. Overexpression of Tiam1 was suggested to be significantly correlated with HCC metastasis. We stably upregulated Tiam1 expression in MHCC97L as well as knocked down Tiam1 expression in HCCLM6. We also investigated the effects of Tiam1 overexpression and knockdown on HCC cells proliferation, migration and invasion in vitro and on tumorigenicity and metastasis in vivo. Overexpression of Tiam1 increased proliferation, migration and invasion of MHCC97L cells, while knockdown of Tiam1 in HCCLM6 cells resulted in the reverse. In vivo functional studies showed upregulation of Tiam1 expres...Continue Reading

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Citations

May 24, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huaimin LiuXiaoli Liu
Jun 18, 2014·Human Genetics·Evangelina López de MaturanaNúria Malats
Apr 3, 2015·European Journal of Clinical Investigation·Bénédicte Delire, Peter Stärkel
Nov 20, 2016·Journal of Biochemical and Molecular Toxicology·Lu LinTong Su
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chun-Hsien ChuH Sunny Sun
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