Tianeptine Abuse and Dependence in Psychiatric Patients: A Review of 18 Case Reports in the Literature

Journal of Psychoactive Drugs
Janusz Springer, Wiesław Jerzy Cubała

Abstract

Tianeptine is an atypical antidepressant approved in 25 countries for the treatment of depressive syndromes. Tianeptine abuse among psychiatric patients in the community and at inpatient wards has been increasingly reported in recent years. The purpose of this article is to alert clinicians to tianeptine abuse potential and identify any patterns in the literature. We searched the Academic Search Complete, Google Scholar, MEDLINE, Science Citation Index, Scopus, and the Social Sciences Citation Index for articles published between 1960-2017 in any language containing the keywords: "tianeptine abuse," "tianeptine misuse," "tianeptine dependence." The search retrieved 18 cases. Higher frequency of tianeptine abuse/dependence was observed in women and 30- to 45-year-olds. Most cases (n = 13) reported a previous history of substance abuse. The therapeutic dose of tianeptine was exceeded 110-fold (i.e., up to 4125 mg/day) with a mean of about 1469 mg/day. The most prominent phenomena associated with tianeptine abuse and dependence were marked euphoria and withdrawal symptoms perpetuating further drug misuse. Tianeptine is a drug with potential for abuse and addiction. Caution should be taken when considering the prescription of tiane...Continue Reading

References

May 19, 1993·European Journal of Pharmacology·G SacchettiR Samanin
Jul 21, 2001·CNS Drugs·A J WagstaffC M Spencer
Feb 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cebrail KisaErol Goka
Jul 17, 2007·Forensic Science International : Synergy·Paula ProençaDuarte Nuno Vieira
Dec 1, 2009·Drug and Alcohol Dependence·José Manuel TrigoRafael Maldonado
May 26, 2010·Human & Experimental Toxicology·Mustafa AriMehmet Duru
Jan 8, 2011·Fundamental & Clinical Pharmacology·Frank RoubyJoëlle Micallef
Dec 15, 2015·Pediatrics·Camille BenceBenjamin Rolland
May 26, 2017·Journal of Analytical Toxicology·Sara K DempseyCarl E Wolf

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Citations

Jul 13, 2018·MMWR. Morbidity and Mortality Weekly Report·Robert GoodnoughPaul D Blanc
Apr 23, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V D Mendelevich
Dec 15, 2018·Journal of Addiction Medicine·Paul Trowbridge, Alexander Y Walley
Apr 29, 2021·The American Journal of Drug and Alcohol Abuse·Kirsten E SmithDavid H Epstein
Mar 7, 2020·Journal of Psychiatric Practice·Asif Karim, Constantine Ioannou

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Software Mentioned

Academic Search Complete
Google Scholar
MEDLINE
Scopus

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