Tianeptine influence on plasmatic catecholamine levels and anxiety index in rats under variable chronic stress after early maternal separation

The International Journal of Neuroscience
Verónica TrujilloM N Suárez

Abstract

The aim of this work was to determine the effect of chronic treatment with 5 mg/kg of tianeptine in male adult Wistar rats separated from the mother as neonates and submitted to variable chronic stress, plasma catecholamines, and anxiety. The plus maze test was performed in order to calculate the anxiety index and catecholamine levels were determined by high-pressure liquid chromatography. Both stress and maternal separation elevated catecholamine levels without affecting anxiety. In the maternally separated stress group, tianeptine decreased epinephrine. Anxiety was reduced in the maternally separated unstressed tianeptine group. Also, all groups showed a tendency to lower anxiety index.

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Citations

Nov 22, 2017·Stress : the International Journal on the Biology of Stress·Antonella PollanoMarta M Suárez
Nov 30, 2018·The International Journal of Neuroscience·Verónica TrujilloMarta Magdalena Suárez
Oct 6, 2012·Pharmacology, Biochemistry, and Behavior·Franciela P DellaJoão Quevedo

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