Tiao Geng decoction for treating menopausal syndrome exhibits anti-aging effects likely via suppressing ASK1/MKK7/JNK mediated apoptosis in ovariectomized rats.

Journal of Ethnopharmacology
Shengnan LiLianwei Xu

Abstract

TG-decoction (Tiao Geng decoction) is the extract of a Chinese herb mixture that has been used for treating menopausal symptoms for over 30 years. We have previously reported anti-aging and anti-oxidative effects of the TG-decoction on hypothalamic neurons in ovariectomized (OVX) rats. The present study further investigates the effects of TG-decoction on the prevention of aging-related ultrastructural changes in menopausal hypothalamic neurons and the likely molecular mechanism. A total of 120 four-month-old female SPF Sprague Dawley rats were divided into six groups. Five groups were ovariectomized (OVX) and one group served as a sham control. Three OVX groups received TG-decoction at three different doses. The remaining two OVX groups served as positive and negative controls by receiving estradiol valerate and saline solution. The sham group received saline. After one month, aging-related ultrastructural alterations in hypothalamic neurons were evaluated using transmission electron microscopy. Nissl staining was used to assess the pathomorphological changes of the hypothalamic neurons. Cell apoptosis was evaluated by TUNEL. Expression of Bcl-2 family genes was studied using qRT-PCR. Expression of the apoptosis-related protein...Continue Reading

References

Jul 27, 2000·Annals of the New York Academy of Sciences·C FranceschiG De Benedictis
Apr 27, 2002·Annals of the New York Academy of Sciences·Eduardo A Porta
Feb 8, 2005·The International Journal of Biochemistry & Cell Biology·Hsin-Chen Lee, Yau-Huei Wei
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Marie A Bogoyevitch, Bostjan Kobe
Oct 22, 2008·Oncogene·D N Dhanasekaran, E P Reddy
Oct 16, 2012·The International Journal of Biochemistry & Cell Biology·Thibaud T RenaultStéphen Manon
Apr 2, 2013·Archives of Toxicology·Krishnendu SinhaParames C Sil
Jan 27, 2015·Archives of Toxicology·Waseem Ahmad SiddiquiHaseeb Ahsan
Jul 28, 2016·Cell Death Discovery·A C FlorS J Kron
Jul 29, 2016·Microbiology and Molecular Biology Reviews : MMBR·András ZekeMarie A Bogoyevitch
Jun 8, 2017·Molecular and Cellular Biochemistry·Seema YadavMrinalini Singh

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