Tiao He Yi Wei Granule, a Traditional Chinese Medicine, against Ethanol-Induced Gastric Ulcer in Mice

Evidence-based Complementary and Alternative Medicine : ECAM
Jinfu Yao

Abstract

Tiao He Yi Wei granule (DHYW), a traditional Chinese medicine, has been used for the treatment of gastric ulcer in clinical setting. The purpose of the present study was to investigate the possible effect of DHYW and explore the underlying mechanism against ethanol-induced gastric ulcer in mice. The model of ethanol-induced gastric ulcer in mice was induced by ethanol (0.2 mL/kg). Administration of DHYW at the doses of 250, 500 mg/kg body weight prior to the ethanol ingestion could effectively protect the stomach from ulceration. The gastric lesions were significantly ameliorated in the DHYW group compared with that in the model group. Treatment with DHYW markedly decreased the levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α). In addition, DHYW treatment elevated myeloperoxidase (MPO) level in stomach, increased superoxide dismutase (SOD) activity, and decreased malonaldehyde (MDA) content in serum and stomach compared with those in the model group. DHYW significantly inhibited NF-κB pathway expressions in the gastric mucosa ulcer group. Taken together, DHYW exerted a gastroprotective effect against gastric ulceration and the underlying mechanism might be associated with NF-κB pathway.

References

Feb 23, 2005·Archives of Surgery·Stephen W Behrman
Jan 18, 2011·Journal of Ethnopharmacology·Elisângela Saturnino de Souza AlmeidaDomingos Tabajara de Oliveira Martins
Dec 3, 2014·Journal of Ethnopharmacology·Long Ma, Jiangguang Liu
Jan 24, 2015·International Immunopharmacology·Tong ChenHui Ji
Feb 1, 2015·Chemico-biological Interactions·Shohda A El-MaraghyNancy N Shahin
Aug 25, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Pengjun XiangHui Ji

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Citations

Apr 20, 2020·Basic & Clinical Pharmacology & Toxicology·Amany Abdel-Mageed AlzokakyNahed A Raslan
Dec 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young-Sik KimHocheol Kim
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Catarina SerafimLeônia Batista

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
MDA
protein assay
ELISA

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