Tibial segmental defect repair: chondrogenesis and biomechanical strength modulated by basic fibroblast growth factor

The Anatomical Record
J L AndreshakF H Wezeman

Abstract

The effect of recombinant human basic fibroblast growth factor (bFGF) on cartilage development and bone biomechanical strength during healing of a tibial segmental defect was studied in the rat. Two reports on the effect of basic FGF administration during fracture healing and several reports on the effects of acidic FGF have documented different responses of callus cartilage to this important growth factor. This is the first report of the effect of bFGF on cartilage formation in the healing of a grafted segmental defect in the rat. The tibiae of 80 male rats underwent segmental resection of the mid-diaphyseal region. One-half of this group consisted of controls that received insertion of an intramedullary wire with a coralline hydroxyapatite graft and Gelfoam without bFGF. The tibiae of the other half were treated identically but had the Gelfoam impregnated with 1 microgram bFGF. Animals were killed at 2, 4, and 8 weeks postoperatively. Histological sections were stained with toluidine blue to differentiate the cartilage. Areas of metachromatically stained extracellular matrix, cell areas, cell size, and cellularity were quantified by using image analysis. Unfixed treated and control tibiae were tested for bone failure strength...Continue Reading

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Citations

Apr 15, 2011·Injury·Kurt D HankensonMara Schenker
Jun 11, 2002·Biochemical and Biophysical Research Communications·Shinji SakanoHisao Seo
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Dec 4, 2003·Drug Discovery Today·Richard A D Carano, Ellen H Filvaroff

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