TICACOS international: A multi-center, randomized, prospective controlled study comparing tight calorie control versus Liberal calorie administration study.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Pierre SingerI Kagan

Abstract

Since the first TICACOS study, 3 additional studies have been published comparing a medical nutrition therapy guided by indirect calorimetry to a regimen prescribed on the basis of predictive equations. A recent guidelines document included a meta-analysis including these 4 papers and found a trend for improvement (OR 0.98-1.48) in favor of medical nutrition therapy guided by indirect calorimetry in terms of survival. The aim of our study was to perform a multicenter prospective, randomized, controlled non blinded study in critically patients to assess the added value for measuring daily resting energy expenditure as a guide for nutritional support. The primary objective was to decrease infectious rate of these critically ill patients. This phase III, multi-center, randomized, controlled non blinded study was planned to include 580 newly-admitted, adult ventilated ICU patients that were planned to stay more than 48 h in the ICU departments. The nutritional support was aimed to meet 80-100% of energy requirement measured by indirect calorimetry. The calorie needs were determined by IC in the Study group and by an equation (20-25 kcal/kg ideal body weight/day) in the Control Group. The ICU staff was trained to strive to supply 80...Continue Reading

References

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Feb 22, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Olav RooyackersJan Wernerman
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Dec 5, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Suzie FerrieKristine Smith
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Nov 12, 2016·Critical Care : the Official Journal of the Critical Care Forum·Oren ZusmanPierre Singer
Nov 8, 2017·Intensive Care Medicine·P SingerP J M Weijs
Oct 23, 2018·The New England Journal of Medicine·UNKNOWN TARGET Investigators, for the ANZICS Clinical Trials GroupPaul Young
Oct 24, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Pierre SingerStephan C Bischoff
Jul 4, 2019·JPEN. Journal of Parenteral and Enteral Nutrition·Haifa MtawehChristopher S Parshuram

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Citations

Dec 29, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Michael P CasaerJan Gunst
Mar 1, 2021·Critical Care : the Official Journal of the Critical Care Forum·Jing-Yi DuanHui-Bin Huang
Mar 27, 2021·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Stephen A McClave, Endashaw Omer
May 3, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Emanuele CeredaRiccardo Caccialanza

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