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Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice

Atherosclerosis

Jun 15, 2018

Byambasuren GanbaatarMasataka Sata

Abstract

Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether tica...read more

Mentioned in this Paper

APOE gene
P2RY12 gene
P2RY12 protein, human
Inflammation
Metabolic Inhibition
Mitogen-Activated Protein Kinase Inhibitor
Quantitative Reverse Transcriptase PCR
Administration Procedure
Atherogenesis
P2ry12 protein, mouse
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Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice

Atherosclerosis

Jun 15, 2018

Byambasuren GanbaatarMasataka Sata

PMID: 29902700

DOI: 10.1016/j.atherosclerosis.2018.05.053

Abstract

Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether tica...read more

Mentioned in this Paper

APOE gene
P2RY12 gene
P2RY12 protein, human
Inflammation
Metabolic Inhibition
Mitogen-Activated Protein Kinase Inhibitor
Quantitative Reverse Transcriptase PCR
Administration Procedure
Atherogenesis
P2ry12 protein, mouse

Similar Papers Found In These Feeds

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