Ticagrelor Added to Aspirin in Acute Nonsevere Ischemic Stroke or Transient Ischemic Attack of Atherosclerotic Origin.

Stroke; a Journal of Cerebral Circulation
Pierre AmarencoTHALES Steering Committee and Investigators*

Abstract

Among patients with a transient ischemic attack or minor ischemic strokes, those with ipsilateral atherosclerotic stenosis of cervicocranial vasculature have the highest risk of recurrent vascular events. In the double-blind THALES (The Acute Stroke or Transient Ischemic Attack Treated With Ticagrelor and ASA for Prevention of Stroke and Death) trial, we randomized patients with a noncardioembolic, nonsevere ischemic stroke, or high-risk transient ischemic attack to ticagrelor (180 mg loading dose on day 1 followed by 90 mg twice daily for days 2-30) or placebo added to aspirin (300-325 mg on day 1 followed by 75-100 mg daily for days 2-30) within 24 hours of symptom onset. The present paper reports a prespecified analysis in patients with and without ipsilateral, potentially causal atherosclerotic stenosis ≥30% of cervicocranial vasculature. The primary end point was time to the occurrence of stroke or death within 30 days. Of 11 016 randomized patients, 2351 (21.3%) patients had an ipsilateral atherosclerotic stenosis. After 30 days, a primary end point occurred in 92/1136 (8.1%) patients with ipsilateral stenosis randomized to ticagrelor and in 132/1215 (10.9%) randomized to placebo (hazard ratio 0.73 [95% CI, 0.56-0.96], P=...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·P AmarencoJ J Hauw
Dec 1, 1994·The New England Journal of Medicine·P AmarencoM G Bousser
Sep 2, 1993·The New England Journal of Medicine·UNKNOWN GUSTO investigators
May 9, 1996·The New England Journal of Medicine·UNKNOWN French Study of Aortic Plaques in Stroke GroupM-G Bousser
Aug 11, 2006·The New England Journal of Medicine·Pierre AmarencoUNKNOWN Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators
Aug 30, 2008·The New England Journal of Medicine·Ralph L SaccoUNKNOWN PRoFESS Study Group
Oct 11, 2008·Stroke; a Journal of Cerebral Circulation·Henrik SillesenUNKNOWN Stroke Prevention by Aggressive Reduction in Cholesterol Levels Investigators
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Aug 31, 2012·The New England Journal of Medicine·UNKNOWN SPS3 InvestigatorsLesly A Pearce
Jun 28, 2013·The New England Journal of Medicine·Yongjun WangUNKNOWN CHANCE Investigators
Jul 19, 2013·Stroke; a Journal of Cerebral Circulation·Gaia SirimarcoPierre Amarenco
Aug 1, 2013·Cerebrovascular Diseases·P AmarencoM G Hennerici
Apr 21, 2016·The New England Journal of Medicine·Pierre AmarencoUNKNOWN TIAregistry.org Investigators
May 11, 2016·The New England Journal of Medicine·S Claiborne JohnstonUNKNOWN SOCRATES Steering Committee and Investigators
May 17, 2018·The New England Journal of Medicine·S Claiborne JohnstonUNKNOWN Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators
May 17, 2018·The New England Journal of Medicine·Pierre AmarencoUNKNOWN TIAregistry.org Investigators
Feb 13, 2019·International Journal of Stroke : Official Journal of the International Stroke Society·S Claiborne JohnstonUNKNOWN THALES Investigators
Sep 3, 2019·The New England Journal of Medicine·P Gabriel StegUNKNOWN THEMIS Steering Committee and Investigators
Nov 19, 2019·The New England Journal of Medicine·Pierre AmarencoUNKNOWN Treat Stroke to Target Investigators
Jul 16, 2020·The New England Journal of Medicine·S Claiborne JohnstonUNKNOWN THALES Investigators
Aug 1, 2019·Stroke; a Journal of Cerebral Circulation·Peter J GodolphinUNKNOWN Adjudicating Outcomes in Stroke Trials Collaboration

❮ Previous
Next ❯

Citations

May 1, 2021·Journal of Clinical Medicine·Leonardo De LucaDomenico Gabrielli
May 5, 2021·Stroke; a Journal of Cerebral Circulation·Shadi YaghiNils Henninger
Jun 25, 2021·Vascular Health and Risk Management·Rahul ChandraKonark Malhotra
Aug 8, 2021·Journal of Clinical Medicine·Akisato NishigakiHideo Wada
Aug 20, 2021·Current Cardiology Reports·Katelyn MarsdenDavid Tirschwell
Aug 31, 2021·European Heart Journal·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Sep 4, 2021·Stroke; a Journal of Cerebral Circulation·S Claiborne JohnstonUNKNOWN THALES Investigators
Sep 25, 2021·European Journal of Preventive Cardiology·Frank L J VisserenUNKNOWN ESC Scientific Document Group
Jun 19, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David J GladstoneAlexandre Y Poppe

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
coronary artery bypass

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved