Ticagrelor Removal From Human Blood

JACC. Basic to Translational Science
George O AngheloiuCarl Whatling

Abstract

The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments. The first set was a first-pass experiment using bovine serum albumin (BSA) solution pre-incubated with ticagrelor, whereas the second set, performed in a recirculating manner, used human blood mixed with ticagrelor. Removal of ticagrelor from BSA solution reached values >99%. The peak removal rate was 99% and 94% from whole blood and 99.99% and 90% from plasma during 10 h and 3 to 4 h of recirculating experiments, respectively. In conclusion, hemadsorption robustly removes ticagrelor from BSA solution and human blood samples.

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Citations

Aug 8, 2019·The New England Journal of Medicine·Deepak L BhattJeffrey I Weitz
Feb 13, 2020·Critical Care : the Official Journal of the Critical Care Forum·Patrick M HonoreDavid De Bels
May 18, 2020·Drugs in R&D·Alexandra A AngheloiuGeorge O Angheloiu
Aug 8, 2019·The New England Journal of Medicine·Karim IbrahimSilvio Quick
Jul 28, 2020·Journal of Clinical Medicine·Anne GodierThe French Working Group On Perioperative Haemostasis Gihp Group
Jun 28, 2020·The Thoracic and Cardiovascular Surgeon·Georg SchlachtenbergerThorsten C W Wahlers
Feb 10, 2021·Journal of Medical Case Reports·Fabio Silvio TacconeDavid Grimaldi
Mar 13, 2021·Pharmacology Research & Perspectives·Paul BieverAchim Lother
Apr 29, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Bernard KrügerCarlos-A Mestres
Aug 14, 2021·Journal of Thrombosis and Thrombolysis·Davide CaoRoxana Mehran
Jan 21, 2022·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Kambiz HassanStephan Geidel

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Methods Mentioned

BETA
coronary

Software Mentioned

Open Office
Apache
CytoSorb

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