Ticagrelor versus clopidogrel in East-Asian patients with acute coronary syndromes: a meta-analysis of randomized trials

Journal of Comparative Effectiveness Research
Bin WuBen He

Abstract

To determine whether ticagrelor or clopidogrel provides the best outcomes for East-Asian patients with acute coronary syndrome (ACS). Identification and interrogation of electronic databases through 26 July 2016 revealed fully randomized and controlled trials wherein primary efficacy end points were major adverse cardiovascular events and all-cause death among East-Asian patients with ACS. Major bleeding and noncoronary artery bypass grafts major bleeding were primary safety end points. Two studies met the inclusion criteria. Compared with clopidogrel, ticagrelor has no statistical difference in the end points of major adverse cardiovascular events (risk ratio [RR]: 1.08; 95% CI: 0.62-1.91; p = 0.7260), myocardial infarction (RR: 1.200; 95% CI: 0.64-2.24; p = 0.5669), stroke (RR: 1.11; 95% CI: 0.46-2.66; p = 0.8165), cardiovascular death (RR: 0.89; 95% CI: 0.48-1.65; p = 0.7150), or all-cause mortality (RR: 0.92; 95% CI: 0.43-1.96; p = 0.8252). When compared with clopidogrel, it was found that ticagrelor provoked marked increases in major bleeding (RR: 1.48; p = 0.0430) and noncoronary artery bypass grafts-associated major bleeding (RR: 1.62; p = 0.0454). Ticagrelor and clopidogrel displayed similar efficacies in ACS presenting...Continue Reading

References

Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 8, 2009·Current Medical Research and Opinion·Michael J Cowley, Louis Kuritzky
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 1, 2009·The New England Journal of Medicine·Lars WallentinMona Thorsén
Jan 19, 2010·Lancet·Christopher P CannonUNKNOWN PLATelet inhibition and patient Outcomes Investigators
Aug 31, 2010·Journal of the American College of Cardiology·Anne Bellemain-AppaixGilles Montalescot
Dec 28, 2012·Expert Opinion on Pharmacotherapy·Wah Wah Htun, Steven R Steinhubl
Apr 1, 2012·European Heart Journal. Acute Cardiovascular Care·Thomas HöchtlKurt Huber
Sep 18, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Shinya GotoTakeshi Kimura
Oct 18, 2015·International Journal of Cardiology·Mark Y ChanYoung-Hoon Jeong

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Citations

Jan 20, 2021·The Pharmacogenomics Journal·Ji Heon KimMark Yan Yee Chan

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Methods Mentioned

BETA
noncoronary artery bypass

Software Mentioned

MetaXL
Google Scholar

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