Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
A M Chudzinski-TavassiJean Gabriel de Souza

Abstract

Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has become quite attractive natural source for coagulation inhibitors, since its saliva has a very rich variety of bioactive molecules. For instance, a Kunitz-type FXa inhibitor, named Amblyomin-X, was found through transcriptome of the salivary gland of the Amblyomma cajennense. tick. This TFPI-like inhibitor, after obtained as recombinant protein, has presented anticoagulant, antigionenic, and antitumor properties. Although its effects on blood coagulation could be relevant for antitumor effect, Amblyomin-X acts by non-hemostatic mechanisms, such as proteasome inhibition and autophagy inhibition. Notably, cytotoxicity was not observed on non-tumor cells treated with this protein, suggesting some selectivity for tumor cells. Considering the current efforts in order to develop effective anticancer therapies, the findings presented in this review strongly suggest Amblyomin-X as a promising novel antitumor drug candidate.

References

Jun 25, 1999·Cell Death and Differentiation·R Z Orlowski
Jul 10, 1999·Science·M Marsh, H T McMahon
May 16, 2002·Traffic·Rafael Garcia-MataElizabeth Sztul
Feb 5, 2008·Toxicon : Official Journal of the International Society on Toxinology·Isabel F C BatistaInácio L M Junqueira-de-Azevedo
Apr 1, 2008·Breast Cancer Research : BCR·Joanne E BluffCarolyn A Staton
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Ivo M B FrancischettiJose M C Ribeiro
Jul 16, 2009·Nature Reviews. Molecular Cell Biology·Harald Stenmark
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jane E MurphyNigel W Bunnett
Feb 11, 2010·Social Psychiatry and Psychiatric Epidemiology·John A RønningAndre Sourander
May 15, 2010·Thrombosis Research·Delphine GarnierJanusz Rak
Jun 24, 2010·Toxicon : Official Journal of the International Society on Toxinology·Ana Marisa Chudzinski-TavassiMarilene Demasi
Apr 13, 2011·Journal of Cell Communication and Signaling·Lisa J CrawfordAlexandra E Irvine
Nov 1, 2008·Molecular Ecology Resources·Chad D WattsScot A Kelchner
May 25, 2011·Journal of the National Cancer Institute·Amy M RuschakAaron D Schimmer
Jul 5, 2011·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Simone Michaela SimonsAna Marisa Chudzinski-Tavassi
Aug 20, 2011·American Journal of Respiratory Cell and Molecular Biology·LaTerrica WilliamsSteven Idell
Sep 1, 2011·The EMBO Journal·Jatta Huotari, Ari Helenius
Jan 28, 2012·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Erica Mie AkagiAna Marisa Chudzinski-Tavassi
May 12, 2012·Toxicon : Official Journal of the International Society on Toxinology·C C DrewesS H P Farsky
Sep 15, 2012·Investigational New Drugs·Durvanei Augusto MariaAna Marisa Chudzinski-Tavassi
Nov 28, 2012·Current Pharmaceutical Design·Daniela BuacQ Ping Dou
Feb 26, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Janaína Souza VenturaAna Marisa Chudzinski-Tavassi
Jan 21, 2015·Revista médica de Chile·Pablo YoungJulio E Bruetman

❮ Previous
Next ❯

Citations

Nov 8, 2017·Medical and Veterinary Entomology·L F PariziI DA Silva Vaz
Sep 22, 2018·Cell Adhesion & Migration·Mariana Costa Braga SchmidtAna Marisa Chudzinski-Tavassi
Apr 15, 2020·Scientific Reports·Flavio LichtensteinAna Marisa Chudzinski-Tavassi
Aug 28, 2016·Oncotarget·Jean Gabriel de SouzaAna Marisa Chudzinski-Tavassi
Jul 25, 2019·Frontiers in Physiology·Iveta ŠtibrániováMária Kazimírová
Jan 23, 2021·International Journal of Molecular Sciences·Mohamed Amine JmelMichalis Kotsyfakis
Dec 10, 2019·Biochimica Et Biophysica Acta. Proteins and Proteomics·Larissa Almeida MartinsMichail Kotsyfakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Protein and Peptide Letters
Kerly Fernanda Mesquita PasqualotoA M Chudzinski-Tavassi
Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Erica Mie AkagiA M Chudzinski-Tavassi
© 2022 Meta ULC. All rights reserved