Abstract
Serious hematologic complications associated with ticlopidine have been reported, including aplastic anemia. We report here an additional case of fatal aplastic anemia due to ticlopidine. A 66-year-old male patient developed fever and pancytopenia 2 months after ticlopidine was started. Despite the administration of granulocyte colony-stimulating factor (G-CSF) and broad-spectrum antibiotics, as well as aggressive red cell and platelet transfusions, the patient died 16 days after admission due to septic shock. Eighteen other cases of ticlopidine-induced aplastic anemia published in the English literature are also reviewed and presented here. Eight of the total 19 patients (including the one reported here) have died, mostly due to infection. Of the seven who received supportive treatment only, four had spontaneous recovery. Nine cases were treated with G-CSF or granulocyte-macrophage colony-stimulating factor (GM-CSF), and response was observed in only four of them. Several other cases were treated with high-dose corticosteroids or androgens; however, it was not possible to evaluate the efficacy of these treatments because of the limited number of cases. In the absence of satisfactory treatment for ticlopidine-induced aplastic a...Continue Reading
Citations
May 1, 1999·The New England Journal of Medicine·F FerrerV Vicente
May 18, 2001·Intensive Care Medicine·C ZaunerR Birnbacher
Oct 20, 2005·Pharmacotherapy·Tammy L BurnsDaniel E Hilleman
Feb 13, 2001·Annual Review of Medicine·J S Bennett
Jul 18, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·M Eda ErtorerRikkat Kocak
Apr 2, 2004·International Journal of Clinical Practice·D J BetteridgeM Pye
Feb 19, 2000·American Journal of Hematology·V A PullarkatH A Liebman
Sep 11, 2002·American Journal of Hematology·A SymeonidisN Zoumbos
Apr 27, 2011·American Journal of Therapeutics·Suraj ChandrasekarRohit Arora
Dec 31, 2009·Journal of Interventional Cardiology·Chetan Shenoy, Kishore J Harjai
Oct 4, 2007·Journal of the American Geriatrics Society·William H ShrankJerry Avorn
Apr 14, 2010·Current Opinion in Cardiology·Miles W BehanPhilip E Aylward
Jan 23, 2015·Thrombosis and Haemostasis·Sakine SimsekyilmazFelix Vogt
Feb 7, 2001·Chest·C PatronoG Roth
Sep 24, 2004·Chest·Carlo PatronoGerald Roth
Nov 20, 1998·Chest·C PatronoG Roth
Jul 24, 2008·Chest·Carlo PatronoGerald Roth
Feb 15, 2012·Chest·John W EikelboomJeffrey I Weitz