TIE-2 expressing monocytes in human cancers

Oncoimmunology
Riccardo TurriniMarie-Agnès Doucey

Abstract

Tumor-associated macrophages (TAM) are well known as a key player in the tumor microenvironment, which support cancer progression. More recently, a lineage of monocytes characterized by the expression of the TIE-2/Tek angiopoietin receptor identified a subset of circulating and tumor-associated monocytes endowed with proangiogenic activity. TIE-2 expressing monocytes (TEM) were found both in humans and mice. Here, we review the phenotypes and functions of TEM reported so far in human cancer and their potential use as markers of cancer progression and metastasis. Finally, we discuss the therapeutic approaches currently used or proposed to target TEM.

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Citations

Feb 13, 2019·Cellular and Molecular Life Sciences : CMLS·Hans Prenen, Massimiliano Mazzone
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Jul 3, 2021·Cancers·Justyna WośAgnieszka Bojarska-Junak

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Methods Mentioned

BETA
xenograft

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