Tie endothelial cell-specific receptor tyrosine kinase is upregulated in the vasculature of arteriovenous malformations

Journal of Neuropathology and Experimental Neurology
E HatvaM Haltia

Abstract

Arteriovenous malformations (AVMs) are congenital lesions composed of abnormal vasculature, with no capillary component, and are clinically significant due to their tendency to spontaneously hemorrhage. The mechanisms regulating the genesis and progression of these lesions are unknown. In order to study the role of angiogenesis in AVMs, we have analyzed the expression of the endothelial cell mitogen vascular endothelial growth factor (VEGF) and a novel endothelial cell-specific receptor tyrosine kinase, Tie, by in situ hybridization and immunohistochemistry in these malformations and surrounding brain tissue. We have previously shown upregulation of Tie accompanying wound healing and tumor progression. In this study, we demonstrate significantly elevated levels of Tie mRNA and protein in AVM and surrounding brain vasculature. Upregulation of VEGF mRNA was observed in the cells of brain parenchyma adjacent to the AVM, and VEGF protein was detected in this tissue as well as in AVM endothelia. Normal brain, in comparison, expressed little or no Tie or VEGF. The significant upregulation of VEGF and Tie in AVMs may indicate some ongoing angiogenesis, possibly contributing to the slow growth and maintenance of the AVM, and could be o...Continue Reading

Citations

Jun 20, 2007·Neurosurgical Review·Atsushi SasaharaIturo Inoue
May 16, 2000·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R HerzigK Urbanek
Apr 13, 2002·Neurosurgery·Ketan R BulsaraCarmelo Graffagnino
Aug 29, 2003·Neurosurgery·Mark R Harrigan
Nov 25, 2003·Neurosurgery·Gelareh Zadeh, Abhijit Guha
Jan 28, 2004·Neurosurgery·Tomoki HashimotoWilliam L Young
Oct 21, 2006·Neurosurgery·Michael J Alexander, Marshall E Tolbert
Jul 11, 2007·Neurosurgery·Reza JahanFernando Viñuela
Nov 26, 2010·Neurosurgery·Mohamed Mostafa AzizSusumu Miyamoto
May 5, 2009·Neurosurgical Focus·Parham MoftakharNeil A Martin
Nov 25, 2005·Journal of Neurosurgery·Marsha J Merrill, Edward H Oldfield
Dec 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jing Fang SunLaura E Benjamin
Feb 10, 2006·Neurosurgical Focus·C StapfE S Connolly
Mar 3, 2012·World Neurosurgery·Mohamed Mostafa AzizSusumu Miyamoto
May 28, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peng GaoWilliam L Young
Nov 13, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kingsley P StorerMarcus A Stoodley
Sep 20, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E JubeliL Moine
Nov 12, 1998·The American Journal of Pathology·J LaurénK Alitalo
Jun 15, 2000·The American Journal of Pathology·L F BrownG D Yancopoulos
Feb 13, 2014·The Journal of International Medical Research·Jie BaiYuan-Li Zhao
Jan 23, 2018·The Journal of Clinical Investigation·Silvia La PortaHellmut G Augustin
Nov 4, 2000·Stroke; a Journal of Cerebral Circulation·S MatsubaraM Letarte
Mar 22, 2003·Stroke; a Journal of Cerebral Circulation·Tomoki HashimotoUNKNOWN University of California, San Francisco BAVM Study Group
Jun 7, 2008·Stroke; a Journal of Cerebral Circulation·Grace H KimE Sander Connolly
Apr 14, 1999·The American Journal of Gastroenterology·F JunqueraJ R Malagelada
Mar 17, 2000·Current Opinion in Neurology·C Stapf, J P Mohr
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kristina IljinKari Alitalo
Sep 1, 1999·Seminars in Cutaneous Medicine and Surgery·F Blei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.