Tie2 vascular endothelial receptor expression and function in hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Shinji TanakaKeizo Sugimachi

Abstract

Hepatocellular carcinoma (HCC) is generally characterized as a hypervascular tumor of rapid growth. We have previously reported that angiopoietin (Ang), a ligand for Tie2 vascular endothelial-specific receptor tyrosine kinase, may play a role in the progression of human HCC (J Clin Invest 1999;103:341-345) and matrix proteinase expression (Cancer Res 2001;61:2145-2153). However, the role of Tie2 receptor in hepatic oncogenesis is unknown. The Tie2 receptor protein was overexpressed in the neovascular endothelium of 31 of 39 (80%) human HCC tumors by immunohistochemical analysis with significant correlation to cell dedifferentiation and tumor size (P <.05). In vitro expression of a dominant-negative construct, containing a soluble Tie2 ectodomain (sTie2), led to Ang protein interaction, inhibition of endogenous Tie2 phosphorylation in vascular endothelial cells and matrix metalloproteinase 9 (MMP-9) suppression. In conclusion, tumorigenicity with neovascularization was suppressed by in vivo gene transfer and sTie2 expression in a murine HCC model, suggesting a possible role for Tie2 expression in the induction of HCC neovascularization and disease progression. Inhibition of the Ang/Tie2 signal transduction cascade is a promising...Continue Reading

References

May 1, 1995·The Journal of Cell Biology·T Mustonen, K Alitalo
Jan 1, 1993·Growth Factors·S Nagata, R Fukunaga
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Oct 7, 1997·Circulation Research·A L WongK G Peters
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·P LinK G Peters
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TanakaK Sugimachi
Aug 26, 1998·The Journal of Clinical Investigation·S TanakaK Sugimachi
Feb 2, 1999·The Journal of Clinical Investigation·S TanakaJ R Wands
Mar 11, 1999·The New England Journal of Medicine·N Ince, J R Wands
Mar 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R NelsonL M Matrisian
Mar 29, 2000·The Journal of Biological Chemistry·A PapapetropoulosW C Sessa
May 8, 2000·Journal of Cellular Physiology·S TanakaJ R Wands
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Dec 15, 2000·Current Opinion in Structural Biology·J H HurleyM A Pearson

❮ Previous
Next ❯

Citations

Apr 20, 2006·International Journal of Clinical Oncology·Shinji Tanaka, Shigeki Arii
May 28, 2010·International Journal of Clinical Oncology·Shinji Tanaka, Shigeki Arii
Apr 20, 2004·Journal of Hepatology·Takuji TorimuraMasamichi Kojiro
Feb 25, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pingchuan LiAlbert Deisseroth
May 30, 2006·Nature Structural & Molecular Biology·William A BartonDimitar B Nikolov
Aug 12, 2003·Human Gene Therapy·Michele De PalmaLuigi Naldini
Sep 16, 2006·Human Gene Therapy·Loree C Heller, Richard Heller
Nov 6, 2003·Journal of Clinical Pathology·K SugimachiM Tsuneyoshi
May 16, 2012·The Journal of Clinical Investigation·Moritz FelchtHellmut G Augustin
Feb 1, 2008·Annals of Surgical Oncology·Roberta W C PangRonnie T P Poon
Dec 29, 2013·Annals of Surgical Oncology·Kousuke OgawaShigeki Arii
Oct 19, 2011·Journal of Oncology·Una AdamcicBrenda L Coomber
Feb 26, 2011·Journal of Gastroenterology·Shinji Tanaka, Shigeki Arii
Nov 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Luni EmdadPaul B Fisher
Jun 24, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Francesca GotschSonia S Hassan
Nov 22, 2005·Expert Opinion on Drug Delivery·Loree C HellerRichard Heller
Sep 22, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Jae Hwan ChoHan Soo Kim
Aug 1, 2012·Seminars in Oncology·Shinji Tanaka, Shigeki Arii
Jun 21, 2005·Alimentary Pharmacology & Therapeutics·X SalcedoR Moreno-Otero
Nov 29, 2008·Cancer Science·Shinji Tanaka, Shigeki Arii
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kota SatoShigeki Arii
Mar 28, 2006·Cancer Letters·Roberta Pang, Ronnie T P Poon
Mar 18, 2015·Experimental Dermatology·Martin TeichertMoritz Felcht
Oct 8, 2004·Expert Opinion on Therapeutic Targets·Yves St-PierreCéline Van Themsche
Oct 28, 2016·Journal of Neurochemistry·Hannah SchneiderMichael Weller
Dec 7, 2018·GigaScience·Weitai HuangCaroline G Lee
May 9, 2014·Oncotarget·Varalakshmi KaturiDavid M Loeb
Mar 12, 2008·Acta Biochimica Et Biophysica Sinica·Xianghua WuJianren Gu
Nov 5, 2020·Cells·Bart VanderborghtLindsey Devisscher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Noboru MitsuhashiMasaru Miyazaki
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
H YoshijiH Fukui
© 2022 Meta ULC. All rights reserved