Tigecycline and the need for a new broad-spectrum antibiotic class

Surgical Infections
Mark H Wilcox

Abstract

Lack of progress in developing new antimicrobials, particularly new classes, as opposed to variants of existing agents, has contributed to the emergence of antibiotic-resistant pathogens. Data synthesis after review of pertinent English-language literature. The development of new classes of antimicrobial agents is crucial, considering the increasing prevalence of nosocomial pathogens resistant to empiric as well as second- and third-line antibiotic choices. Tigecycline has recently been approved for the treatment of complicated skin and skin structure as well as intra-abdominal infections. Published data on the in vitro and in vivo properties of tigecycline, the first-in-class glycylcycline, are reviewed. It is plausible that tigecycline could to some extent replace available broadspectrum agents for approved indications and thereby reduce the selective pressure for some currently prevalent multi-resistant pathogens in the hospital setting.

References

Mar 5, 1998·JAMA : the Journal of the American Medical Association·B C HeroldR S Daum
Feb 2, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·N S CrowcroftR Mertens
Oct 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G LinaJ Etienne
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E J GorakJ D Brown
Mar 9, 2000·The New England Journal of Medicine·B E Murray
Jul 18, 2000·Antimicrobial Agents and Chemotherapy·H W BoucherG M Eliopoulos
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M WebbR B Roberts
Aug 7, 2001·Annals of Internal Medicine·S K FridkinUNKNOWN Intensive Care Antimicrobial Resistance Epidemiology (ICARE) Project and the National Nosocomial Infections Surveillance (NN
Feb 19, 2002·Antimicrobial Agents and Chemotherapy·Carmen BetriuUNKNOWN Spanish Group of Tigecycline
May 29, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peter C Appelbaum
Jun 1, 2002·The Journal of Antimicrobial Chemotherapy·Eileen M Graffunder, Richard A Venezia
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philippe DufourHervé Richet
Oct 24, 2002·Archives of Internal Medicine·Yehuda CarmeliMatthew Samore
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E CosgroveYehuda Carmeli
Jan 25, 2003·Surgical Infections·Joseph A PaladinoJerome J Schentag
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Melissa A VisalliPatricia A Bradford
Feb 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ebbing LautenbachNeil O Fishman
Feb 21, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John J EngemannKeith S Kaye
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Arno A MullerXavier Bertrand
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson, Louis B Rice
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carl UrbanJames J Rahal
Sep 27, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Cassandra D Salgado, Barry M Farr
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kanokporn MongkolrattanothaiRobert S Daum
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Corinne ArpinClaudine Quentin
Nov 14, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M MelzerS Chinn
Jan 14, 2004·Emerging Infectious Diseases·Stephen G WeberYehuda Carmeli
Jan 16, 2004·Drugs·George G ZhanelDaryl J Hoban
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Brad SpellbergJohn E Edwards
May 7, 2004·The Journal of Antimicrobial Chemotherapy·Rosy ReynoldsUNKNOWN BSAC Extended Working Party on Bacteraemia Resistance Surveillance

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Citations

Jun 24, 2008·Surgical Infections·Philip S Barie
Mar 18, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Yi YangJianghua Chen
Dec 18, 2010·European Journal of Medical Research·K S Estes, Hartmut Derendorf
Dec 19, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K-F Bodmann, UNKNOWN und die Expertenkommission der Infektliga
Jul 26, 2011·Journal of Cataract and Refractive Surgery·Omid AboualiGoodarz Ahmadi
May 19, 2011·Indoor Air·Y Li, P V Nielsen
Mar 26, 2014·International Forum of Allergy & Rhinology·Kai Zhao, Jianbo Jiang
Nov 16, 2010·Medical Engineering & Physics·Katharine H FraserZhongjun J Wu
May 1, 2016·Journal of Colloid and Interface Science·Samuel Martin, Bharat Bhushan
Mar 13, 2002·Acta Veterinaria Scandinavica·M HeinonenV Tuovinen
Oct 17, 2016·The Science of the Total Environment·Giuseppe Roberto PisaturoValentina Cavedon
Sep 4, 2009·Clinical Pharmacokinetics·April BarbourHartmut Derendorf

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