Tigecycline Inhibits Glioma Growth by Regulating miRNA-199b-5p-HES1-AKT Pathway

Molecular Cancer Therapeutics
Rui YangHongjuan Cui

Abstract

Tigecycline is a broad-spectrum, first-in-class glycylcycline antibiotic currently used to treat complicated skin infections and community-acquired pneumonia. However, there is accumulating evidence showing that tigecycline has anticancer properties. In this study, we found tigecycline could inhibit cell proliferation by inducing cell-cycle arrest, but not apoptosis in glioma. To find the underlying mechanism of how tigecycline inhibits cell proliferation, the expression of miRNAs, which were related to regulating cell-cycle progression, was detected with miRNA assay. We found that miR-199b-5p expression was significantly increased after tigecycline treatment, and miR-199b-5p target gene HES1 was downregulated. In addition, the PI3K/AKT pathway was inhibited and p21 expression was increased. When treated with tigecycline and miR-199b-5p antagomir simultaneously in glioma cells, we found that miR-199b-5p antagomir could partly block the effects induced by tigecycline. Tigecycline effectively upregulated miR-199b-5p expression and inhibited tumor growth in the xenograft tumor model of U87 glioma cells. These results suggest that tigecycline may induce cell-cycle arrest and inhibit glioma growth by regulating miRNA-199b-5p-HES1-AK...Continue Reading

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Citations

Apr 2, 2016·Biochemical and Biophysical Research Communications·Yiting ZhangZhenping Huang
May 29, 2016·Cellular and Molecular Life Sciences : CMLS·Sivadasan Bindu DhaneshJackson James
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yiting ZhangZhenping Huang
Sep 25, 2018·Journal of Cellular and Molecular Medicine·Ruye MaShenghui Zhang
Oct 21, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M N AbbasH Cui
Mar 4, 2020·International Journal of Oncology·Zhen DongHongjuan Cui
Apr 17, 2019·Journal of Experimental & Clinical Cancer Research : CR·Hua JinCheng-Xiong Xu
Aug 21, 2020·British Journal of Cancer·Rui YangHongjuan Cui
Dec 21, 2016·Frontiers in Pharmacology·Zhijie XuZhicheng Gong
Oct 12, 2018·Cell Death & Disease·Kui ZhangHongjuan Cui
Jul 25, 2019·International Journal of Molecular Sciences·Zhen DongHongjuan Cui
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Longchang BaiHongjuan Cui
Nov 6, 2021·Experimental and Therapeutic Medicine·Gaoting QuAiqing Zhang

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