Tight junctions form a barrier in porcine hair follicles

European Journal of Cell Biology
Christiane MathesClaus-Michael Lehr

Abstract

Follicular penetration has gained increasing interest regarding (i) safety concerns about (environmentally born) xenobiotics available to the hair follicle (HF), e.g. nanomaterials or allergens which should not enter the skin, and (ii) the possibility for non-invasive follicular drug and antigen delivery. However, not much is known about barriers in the HF which have to be surpassed upon uptake and/or penetration into surrounding tissue. Thus, aim of this work was a detailed investigation of this follicular barrier function, as well as particle uptake into the HF of porcine skin which is often used as a model system for human skin for such purposes. We show that follicular tight junctions (TJs) form a continuous barrier from the infundibulum down to the suprabulbar region, complementary to the stratum corneum in the most exposed upper follicular region, but remaining as the only barrier in the less accessible lower follicular regions. In the bulbar region of the HF no TJ barrier was found, demonstrating the importance of freely supplying this hair-forming part with e.g. nutrients or hormones from the dermal microenvironment. Moreover, the dynamic character of the follicular TJ barrier was shown by modulating its permeability us...Continue Reading

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Sep 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexa PatzeltJürgen Lademann
Jul 18, 2019·Expert Opinion on Drug Delivery·Yang ChenShengnan Meng
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Aug 18, 2021·Advanced Drug Delivery Reviews·Michael S RobertsJeffrey E Grice

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