TIGIT-CD155 Interactions in Melanoma: A Novel Co-Inhibitory Pathway with Potential for Clinical Intervention

The Journal of Investigative Dermatology
Karsten Mahnke, Alexander H Enk

Abstract

Inozume et al. describe a novel immunosuppressive mechanism in melanoma that is triggered by the interaction between CD155 (expressed by melanomas) and T-cell Ig and ITIM domain (TIGIT) (expressed by tumor infiltrating lymphocytes). This pathway exists in addition to the "classical" co-inhibitory PD-1-PD-L1 pathway. Hence, the combinatorial blockage of both pathways by specific antibodies resulted in the greatly enhanced effector function of melanoma-specific cytotoxic T cells. Given that CD155-TIGIT signaling exerts potent inhibitory action in different subsets of immune cells and that CD155 is expressed broadly in several tumor entities, this report points toward a novel and promising therapeutic strategy to combine different checkpoint blocking agents for greater success in antitumor therapy.

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Citations

Jan 12, 2017·Cell Communication and Signaling : CCS·Kemal CatakovicRoland Geisberger
Dec 24, 2017·Journal of Cellular Biochemistry·Jin-Cheng WangXiao-Jie Lu
Sep 11, 2019·Journal for Immunotherapy of Cancer·Shiran HoogiCyrille J Cohen
Dec 31, 2016·Human Antibodies·Natan SteinOfer Mandelboim
Jun 14, 2020·Journal of Hematology & Oncology·Kyle B Lupo, Sandro Matosevic
Dec 20, 2018·Frontiers in Neurology·Adonis SferaCarolina Osorio
Apr 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alex MirandaBrad H Nelson
Mar 10, 2021·Expert Opinion on Emerging Drugs·Vito VanellaPaolo Antonio Ascierto
Jan 23, 2021·Expert Review of Clinical Immunology·Azadehsadat RazaviNima Rezaei

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