TIGIT limits immune pathology during viral infections.

Nature Communications
Michelle SchorerNicole Joller

Abstract

Co-inhibitory pathways have a fundamental function in regulating T cell responses and control the balance between promoting efficient effector functions and restricting immune pathology. The TIGIT pathway has been implicated in promoting T cell dysfunction in chronic viral infection. Importantly, TIGIT signaling is functionally linked to IL-10 expression, which has an effect on both virus control and maintenance of tissue homeostasis. However, whether TIGIT has a function in viral persistence or limiting tissue pathology is unclear. Here we report that TIGIT modulation effectively alters the phenotype and cytokine profile of T cells during influenza and chronic LCMV infection, but does not affect virus control in vivo. Instead, TIGIT has an important effect in limiting immune pathology in peripheral organs by inducing IL-10. Our data therefore identify a function of TIGIT in limiting immune pathology that is independent of viral clearance.

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Citations

Jul 14, 2020·Frontiers in Immunology·Adonis SferaJose E Campo Maldonado
Sep 25, 2020·Viruses·Huiming CaiQinchang Zhu
Jan 24, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hugo BarraguéEric Champagne
Feb 12, 2021·The FEBS Journal·Camilla PanettiNicole Joller
Mar 3, 2021·Current Rheumatology Reports·Stinne Ravn Greisen, Bent Deleuran
Feb 27, 2021·Cancer Immunology, Immunotherapy : CII·Rongpu LiangBo Wei
Dec 24, 2020·International Journal of Molecular Sciences·Yong-Bin ChoYoung-Jin Seo
Jul 14, 2021·Trends in Microbiology·Timothy R McCullochFernando Souza-Fonseca-Guimaraes

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Methods Mentioned

BETA
transgenic
flow cytometry
FACS
light microscopy
bronchoalveolar lavage
FCS

Software Mentioned

Flowjo
FCAP Array
TIGIT
LEGENDplex

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