Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii

Bioorganic & Medicinal Chemistry Letters
Yi-Hua PeiSei-Ryang Oh

Abstract

Bioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene-16-hydroxyphorbol-13-acetate (1) along with four known compounds, 12-O-hexadecanoyl-7-oxo-5-ene-phorbol-13-acetate (2), 12-O-hexadecanoyl-phorbol-13-acetate (3), 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (4), and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate (5). The structures of these compounds were determined by interpretation of NMR (1D and 2D) spectroscopic data and MS data. All the isolates were evaluated for their effects on the induction of IFN-γ in NK92 cells. Compounds 3 and 4 exhibited the most potent responses in IFN-γ induction, comparable to the positive control, phorbol 12-myristate 13-acetate (PMA).

Citations

Apr 23, 2013·Journal of Asian Natural Products Research·Rui WangYan-Ping Shi
Jun 17, 2016·Phytotherapy Research : PTR·Md Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Aug 15, 2013·Natural Product Reports·James R Hanson
Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam
Apr 24, 2015·Chemical Reviews·Hong-Bing WangTing-Guo Kang
May 24, 2019·Journal of Natural Products·Jiao-Jiao CuiJian-Min Yue

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