Tilapia Skin Peptides Ameliorate Diabetic Nephropathy in STZ-Induced Diabetic Rats and HG-Induced GMCs by Improving Mitochondrial Dysfunction.

Marine Drugs
Lin JinXi Xie

Abstract

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes, and mitochondrial dysfunction has been observed in the kidneys of diabetic patients. Tilapia skin peptides (TSPs) are mixtures of small-molecular-weight peptides derived from tilapia skin. Rising evidence suggests that bioactive peptides from marine sources are beneficial for DN. This study aimed to investigate whether TSPs can alleviate the pathological progress in experimental DN by improving mitochondrial dysfunction through the activation of Bnip3/Nix signaling. In the current study, TSPs treatment alleviated the metabolic parameters and renal morphology in streptozotocin-induced diabetic rats. Additionally, TSPs treatment significantly activated Bnip3/Nix signaling and improved the mitochondrial morphology, reversed the over-production of mitochondrial superoxide and cellular reactive oxygen species and the decreased mitochondrial membrane potential, thereby inhibiting the expressions of fibronectin, collagen IV and intercellular cell adhesion molecule-1 in glomerular mesangial cells induced by high glucose. Collectively, our results suggest that TSPs show the renoprotective effect on DN by improving mitochondrial dysfunction, and they c...Continue Reading

References

Jan 23, 1999·The American Journal of Cardiology·R A Kreisberg
Apr 9, 2005·American Journal of Physiology. Renal Physiology·Mariana G RoscaMiriam F Weiss
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tianzheng YuYisang Yoon
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Melinda T CoughlanJosephine M Forbes
Mar 12, 2009·Current Medicinal Chemistry·Imtiaz M ShahGerard A McKay
Dec 17, 2009·EMBO Reports·Ivana NovakIvan Dikic
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Oct 30, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S O KolsetT Jenssen
Mar 13, 2013·Nature Reviews. Endocrinology·K George M M Alberti, Paul Zimmet
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Apr 12, 2014·British Journal of Pharmacology·G C Higgins, M T Coughlan
Oct 2, 2014·Journal of the American Society of Nephrology : JASN·Ming ZhanYashpal S Kanwar
Jan 30, 2015·Critical Reviews in Food Science and Nutrition·Khalid GulRifat Jabeen
Dec 10, 2015·Cellular and Molecular Life Sciences : CMLS·Paolo E PorporatoPierre Sonveaux
Jan 31, 2016·Journal of the American Society of Nephrology : JASN·Bernard A AyangaFarhad R Danesh
Dec 2, 2017·Nutrients·Ahmad AlkhatibJaakko Tuomilehto
Sep 13, 2018·American Journal of Physiology. Renal Physiology·Dan XuWei Zhang
Oct 26, 2018·Journal of Agricultural and Food Chemistry·Xuming DengShili Sun
Jan 9, 2019·The Journal of Endocrinology·Jia SunHuiya Huang
May 28, 2019·Nutrition Reviews·Hanna Fjeldheim DaleGülen Arslan Lied
Jul 28, 2019·Endocrine Connections·Yiqiong MaGuohua Ding
Aug 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dong-Dong LiWei-Xiang Tan
Sep 14, 2019·Cell Death & Disease·Chengyuan TangZheng Dong
Oct 28, 2019·Journal of the Science of Food and Agriculture·Xiaoyun XiongYi Liu
Feb 13, 2020·Journal of Clinical Medicine·Javier Donate-CorreaJuan F Navarro-González

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay

Software Mentioned

SPSS
Image
Pro Plus
ImageJ

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2021 Meta ULC. All rights reserved