Abstract
The purpose of this study was to compare the pharmacokinetics and relative bioavailability of tilmicosin enteric granules and premix after oral administration at a dose of 40 mg/kg in pigs. Three kinds of different respiratory pathogens were selected for determination of minimal inhibitory concentration (MIC) to tilmicosin. Eight healthy pigs were assigned to a two-period, randomized crossover design. A modified rapid, sensitive HPLC method was used for determining the concentrations of tilmicosin in plasma. Pharmacokinetic parameters were calculated by using WinNonlin 5.2 software. The MIC90 of tilmicosin against Haemophilus parasuis, Actinbacillus pleuropneumoniae, and Pasteurella multocida were all 8 μg/ml. These results indicated that these common pig respiratory bacteria are sensitive to tilmicosin. The main parameters of time to reach maximum plasma concentration (Tmax ), elimination half-life (t1/2β ), mean residence time (MRT), and apparent volume of distribution (VF ) were 2.03 ± 0.37 hr, 29.31 ± 5.56 hr, 25.22 ± 2.57 hr, 4.06 ± 1.04 L/kg, and 3.05 ± 0.08 hr, 17.06 ± 1.77 hr, 15.55 ± 1.37 hr, 2.95 ± 0.62 L/kg after the orally administrated tilmicosin enteric granules and premix. The relative bioavailability of tilmicos...Continue Reading
References
Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Sep 1, 1995·Journal of Clinical Microbiology·S A SalmonR J Yancey
Oct 1, 1995·Journal of Veterinary Pharmacology and Therapeutics·G ZivA Saran
Jan 1, 1997·Research in Veterinary Science·A Ramadan
Sep 10, 1998·Journal of Veterinary Pharmacology and Therapeutics·B Scorneaux, T R Shryock
Oct 17, 1998·Poultry Science·B Scorneaux, T R Shryock
Jan 14, 1999·Journal of Veterinary Pharmacology and Therapeutics·S ModricH Derendorf
Jul 1, 1999·Journal of Dairy Science·B Scorneaux, T R Shryock
Dec 7, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D C DeRosaT R Shryock
Nov 9, 2002·Journal of Veterinary Pharmacology and Therapeutics·G ChristodoulopoulosG C Fthenakis
Aug 6, 2003·Preventive Veterinary Medicine·A G J VelthuisJ H M Verheijden
Apr 29, 2004·Journal of Agricultural and Food Chemistry·Yue ZhangJunlin Guo
Jun 3, 2004·Veterinary Microbiology·Frank M AarestrupØystein Angen
Jul 13, 2005·American Journal of Veterinary Research·Jianzhong ShenXiaowei Li
Jan 17, 2007·Veterinary Research Communications·E A Abu-BashaA F Al-Shunnaq
Mar 18, 2009·Journal of Veterinary Pharmacology and Therapeutics·C HanW Z Zhou
Jul 1, 2009·Veterinary Microbiology·Xueli ZhouXuwang Cai
Feb 18, 2011·Journal of Veterinary Pharmacology and Therapeutics·K R LombardiR P Hunter
May 20, 2014·Veterinary Microbiology·Anno de JongMichel Vallé
Nov 2, 2018·The Journal of Veterinary Medical Science·Jincheng XiongYinsheng Qiu
Citations
Oct 8, 2019·Veterinary Medicine and Science·Zhen DongJi-Yu Zhang
Jun 17, 2020·Journal of Veterinary Pharmacology and Therapeutics·Jincheng XiongHaiyang Jiang
Mar 7, 2020·Journal of Veterinary Pharmacology and Therapeutics·Nan ZhangHuanzhong Ding
Jun 19, 2019·New Zealand Veterinary Journal·J XiongJ Cao
Dec 4, 2020·Journal of Veterinary Pharmacology and Therapeutics·Nan ZhangHong Yang