PMID: 4670433Jan 1, 1972

Tilorone hydrochloride: lack of correlation between interferon induction and viral protection

Antimicrobial Agents and Chemotherapy
D J GironF F Pindak

Abstract

The protection of mice against MM virus infection and the induction of circulating interferon by tilorone hydrochloride were determined. Whereas protection was evident with doses of 0.15 and 1.5 mg/kg, interferon was not detected with doses lower than 150 mg/kg. Protection was apparently not dependent on interferon induction.

References

May 1, 1968·The Journal of General Virology·E De Maeyer, J De Maeyer-Guignard
Sep 18, 1970·Science·R F Krueger, G D Mayer
Sep 18, 1970·Science·G D Mayer, R F Krueger
Feb 1, 1971·The Journal of Infectious Diseases·E De Clercq, T C Merigan

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