Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right.

Developmental Cell
Nicole Santos, Jeremy F Reiter

Abstract

Nodal flow orients the left-right axis in some vertebrates, and is generated by clockwise-rotating cilia that are tilted posteriorly. In a recent paper, Song et al. add to mounting evidence that the planar cell polarity (PCP) pathway coordinates posterior positioning of cilia and subsequent determination of left-right asymmetry.

Citations

Dec 14, 2011·Differentiation; Research in Biological Diversity·Anika LangeHeiko Lickert
Nov 17, 2011·Genesis : the Journal of Genetics and Development·Laura N Vandenberg, Michael Levin
Oct 28, 2019·Current Opinion in Cell Biology·Jeffrey D Axelrod
Oct 22, 2013·Genes & Development·Maja Matis, Jeffrey D Axelrod

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