Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation.

Genetics
Kenneth M Weiss

Abstract

Recent years have seen great advances in generating and analyzing data to identify the genetic architecture of biological traits. Human disease has understandably received intense research focus, and the genes responsible for most Mendelian diseases have successfully been identified. However, the same advances have shown a consistent if less satisfying pattern, in which complex traits are affected by variation in large numbers of genes, most of which have individually minor or statistically elusive effects, leaving the bulk of genetic etiology unaccounted for. This pattern applies to diverse and unrelated traits, not just disease, in basically all species, and is consistent with evolutionary expectations, raising challenging questions about the best way to approach and understand biological complexity.

References

Jan 23, 1999·Nature Genetics·A Chakravarti
Jul 3, 1999·Trends in Genetics : TIG·C R Scriver, P J Waters
Jun 3, 2000·Genetics·J K PritchardP Donnelly
Oct 4, 2000·Nature Genetics·K M Weiss, J D Terwilliger
Oct 19, 2000·Advances in Genetics·D C Rao
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·G Doblhammer, J W Vaupel
Aug 30, 2001·Trends in Genetics : TIG·D E Reich, E S Lander
Sep 21, 2001·American Journal of Human Genetics·J AltmüllerM Wjst
Oct 11, 2001·American Journal of Human Genetics·H H GöringJ Blangero
Nov 9, 2001·Annual Review of Genetics·T F Mackay
Nov 9, 2001·Annual Review of Genetics·M H MeislerA Escayg
Dec 6, 2001·Nature Reviews. Genetics·S E Folstein, B Rosen-Sheidley
Dec 26, 2001·Trends in Genetics : TIG·Kenneth M Weiss, Andrew G Clark
Aug 22, 2002·Journal of the National Cancer Institute·Colin B Begg
Oct 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexey S KondrashovFyodor A Kondrashov
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tomoko Ohta
May 2, 2003·Perspectives in Biology and Medicine·Kenneth M Weiss, Anne V Buchanan
Jun 27, 2003·Lancet·Mark CaulfieldUNKNOWN MRC British Genetics of Hypertension Study
Oct 25, 2003·Science·Mary-Claire KingUNKNOWN New York Breast Cancer Study Group
Oct 31, 2003·Trends in Genetics : TIG·David B GoldsteinNicholas W Wood
Dec 3, 2003·Annals of Medicine·Joseph D Terwilliger, Kenneth M Weiss
Jun 3, 2004·Current Opinion in Genetics & Development·John Blangero
Jul 23, 2004·Nature·Michael MorleyVivian G Cheung
Nov 16, 2004·Nature Genetics·John P A IoannidisThomas A Trikalinos
Jan 7, 2005·BMC Pulmonary Medicine·Janine AltmüllerMatthias Wjst
Jan 22, 2005·Trends in Genetics : TIG·Kenneth M Weiss
Mar 17, 2005·Science·Stephen P Daiger
Apr 6, 2005·Human Molecular Genetics·Albert H C WongArturas Petronis
May 14, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jason H Moore, Scott M Williams
Jul 8, 2005·American Journal of Human Genetics·Dominic P Kwiatkowski
Dec 20, 2005·Epilepsia·Ruth Ottman
Jan 6, 2006·Genes and Immunity·C Ober, S Hoffjan
Feb 18, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining ChenGiovanni Parmigiani
Mar 17, 2006·International Journal of Epidemiology·Anne V BuchananStephanie M Fullerton
May 16, 2006·Trends in Genetics : TIG·Arturas Petronis
May 23, 2006·Trends in Genetics : TIG·David M Evans, Lon R Cardon
Jun 3, 2006·Obesity·Tuomo RankinenClaude Bouchard
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Sep 27, 2006·Nature Neuroscience·Francesca HappéRobert Plomin
Nov 11, 2006·Annual Review of Genetics·Adrian V S Hill
Nov 11, 2006·The Behavioral and Brain Sciences·Matthew C Keller, Geoffrey Miller
Nov 23, 2006·Lancet·Dyonne T HartongThaddeus P Dryja

❮ Previous
Next ❯

Citations

May 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Randolph M NesseGilbert S Omenn
Mar 18, 2010·European Journal of Human Genetics : EJHG·Angus J Clarke, David N Cooper
Mar 29, 2012·European Journal of Human Genetics : EJHG·Ros HastingsMartina C Cornel
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·James H BullardRachel B Brem
Jun 19, 2013·Rejuvenation Research·Alexander M Kulminski
Feb 10, 2012·Molecular Biology and Evolution·Hilary C MartinRachel B Brem
Nov 17, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kees van Oers, Jakob C Mueller
May 17, 2012·Genome Research·David T BurkeAndrzej T Galecki
Aug 11, 2011·Genetics·Kenneth M Weiss, Anne V Buchanan
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Randolph M NesseDavid Valle
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·David Houle
Feb 27, 2010·Proceedings of the National Academy of Sciences of the United States of America·Adam Eyre-Walker
Dec 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Randolph M Nesse
Mar 31, 2011·Neurochemical Research·Beatrix GyetvaiCsaba Vadász
Dec 9, 2015·Journal of Evolutionary Biology·W Trible, Kenneth G Ross
Mar 21, 2016·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M Pérez-Enciso, A Legarra
Feb 1, 2009·Evolutionary Applications·Evelyne Heyer, Lluis Quintana-Murci
Feb 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne V BuchananKenneth M Weiss
Sep 13, 2011·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·B YangM Pérez-Enciso
Sep 17, 2013·Evolution; International Journal of Organic Evolution·Zachariah GompertC Alex Buerkle
Mar 1, 2011·Evolutionary Applications·Andrew P HendryScott P Carroll
Mar 1, 2011·Evolutionary Applications·Bernard J Crespi
Oct 31, 2012·Evolution; International Journal of Organic Evolution·Sara J OppenheimKeith R Hopper
Jan 30, 2013·Evolution; International Journal of Organic Evolution·Michael Travisano, Ruth G Shaw
Oct 10, 2013·Molecular Ecology·Zachariah Gompert, C Alex Buerkle
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Feb 26, 2016·Cellular and Molecular Life Sciences : CMLS·Silvia SacchiLoredano Pollegioni
May 10, 2015·Genetics, Selection, Evolution : GSE·Miguel Pérez-EncisoAndrés Legarra
Jan 14, 2011·Trends in Genetics : TIG·Martha T HamblinJean-Luc Jannink
Nov 13, 2012·Trends in Genetics : TIG·Annalise B Paaby, Matthew V Rockman
Nov 7, 2019·Sports Medicine·Michael J Joyner
Oct 5, 2018·Evolution Letters·Elizabeth G MandevilleC Alex Buerkle
Jul 16, 2019·Medicine and Science in Sports and Exercise·Michael J Joyner
Nov 27, 2016·Acta Physiologica·C LundbyM Joyner
Jun 13, 2021·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Frank J MessinaZachariah Gompert
Dec 10, 2013·Genome Research·Carlo G Artieri, Hunter B Fraser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.