Tiludronate infusion in the treatment of bone spavin: a double blind placebo-controlled trial

Equine Veterinary Journal
M R GoughR K W Smith

Abstract

Tiludronate regulates bone remodelling through a decrease of the resorptive process and should therefore ameliorate the remodelling processes active in osteoarthritis of the distal tarsal joints ('bone spavin') and alleviate pain associated with abnormal bone lysis. To confirm the efficacy of tiludronate, administered as a single infusion at a dose of 1 mg/kg bwt, in the treatment of bone spavin in the horse. A double blind placebo controlled trial on 108 clinical cases of bone spavin was undertaken. The lameness score of the lamest limb was assessed following distal tarsal analgesia of the contralateral limb and followed-up using the same procedure throughout the study. Bone spavin in the lamest limb was confirmed by distal tarsal analgesia and radiography. Horses were treated at Day 0 and reassessed 60 days later after controlled exercise. A second nonblinded treatment was given to unresponsive horses and all horses were re-examined at Day 120. Exercise levels were recorded at each examination. Eighty-seven horses completed the trial as per the protocol. The tiludronate horses were significantly less lame than the placebo horses (P = 0.0318). Horses treated at Day 60 with tiludronate showed further improvement in lameness at ...Continue Reading

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Citations

Sep 28, 2012·American Journal of Veterinary Research·Katja F Duesterdieck-ZellmerJesse F Ott
Mar 28, 2013·American Journal of Veterinary Research·Jorge E NietoJack R Snyder
Mar 23, 2017·The Veterinary Clinics of North America. Equine Practice·Alonso Guedes
Mar 21, 2018·BMC Veterinary Research·Heather A RichbourgMargaret A McNulty
Jun 13, 2017·Equine Veterinary Journal·J McLellan
Dec 2, 2017·Equine Veterinary Journal·M A PopotY Bonnaire
Aug 29, 2018·Equine Veterinary Journal·A MitchellA E Watts
Apr 24, 2013·Bone & Joint Research·C W McIlwraithC E Kawcak
Jun 27, 2019·BMC Veterinary Research·Alexis MitchellLarry J Suva

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