PMID: 795403Dec 17, 1976

Time -- a key in experimental and practical medicine

Archives of Toxicology
H Mayersbach


This paper gives an overview on circadian rhythms which governs visibly all biological features. By illustrative examples of circadian rhythms of man and experimental animals it is shown that: 1. The components of all tissues, organs, and blood undergo circadian changes, manifested in drmatic morphologic and chemical differences. These circadian changes simply do not represent minute "physiologic" variations around a 24-h means. 2. The endogenous nature and the influences of the environmental factors such as food, light, laboratory stress, and seasons acting on circadian rhythms are demonstrated. 3. The different circadian phases determine significantly the in vivo and in vitro results in response to hormones, drugs and poisons. The neccessity to consider circadian rhythms is shown by chronotoxicologic experiments: mortality rates between 0 and 100% may occur after application of identical doses of a given drug at different day times.


Dec 17, 1976·Archives of Toxicology·K M Philippens
Dec 17, 1976·Archives of Toxicology·G SteinbachW Poesche
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·A H Meier, A J Fivizzani
Nov 1, 1973·Clinical Pharmacology and Therapeutics·M C Ede
Dec 1, 1974·Journal of Clinical Ultrasound : JCU·R J BartrumJ Dantono
Dec 31, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·B Kaissling, O Bucher
Jan 1, 1971·Annual Review of Pharmacology·A Reinberg, F Halberg
Aug 1, 1972·The American Journal of Physiology·J D DunnP Millet
Feb 1, 1972·The American Journal of Physiology·L E SchevingW H Harrison
Jul 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J J Gagliardino, O R Rebolledo
Apr 1, 1968·The Anatomical Record·L E SchevingJ E Pauly
Oct 1, 1968·The American Journal of Physiology·L E SchevingJ E Pauly
Dec 1, 1965·Comparative Biochemistry and Physiology·J Aschoff, R Wever
Jan 1, 1966·Comparative Biochemistry and Physiology·J J Chiakulas, L E Scheving
Jun 1, 1953·The American Journal of Medicine·L J VORHAUS, R M KARK
May 1, 1959·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M WACHSTEIN, E MEISEL


Jan 15, 1979·International Archives of Occupational and Environmental Health·R J Jaeger
Mar 1, 1979·International Journal of Biometeorology·O HérouxM Normand
Jan 1, 1979·International Journal of Immunopharmacology·R Pownall, M S Knapp
Jan 1, 1987·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y G Kaminsky, E A Kosenko
Apr 1, 1978·European Journal of Clinical Investigation·G Schlierf
May 1, 1990·Journal of Gastroenterology and Hepatology·Y Uchiyama
Sep 1, 1981·Archives of Toxicology·K PüschelH von Mayersbach
Jan 1, 1986·Chronobiology International·I Sauerbier
Oct 20, 2006·Physiology & Behavior·Björn Lemmer
Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·R D Bhattacharya, H von Mayersbach
Dec 1, 1979·International Journal of Biometeorology·A Sieck
Jan 1, 1981·Scandinavian Journal of Gastroenterology·A MarkiewiczH Bołdys
Jul 28, 2001·Chronobiology International·E J PiccoJ C Boggi

Related Concepts

Circadian Rhythms
Food Deprivation (Experimental)
Seasonal Variation

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