Time- and dose-dependency of radiographic normal tissue changes of the lung after stereotactic radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Holger HofChristian Plathow

Abstract

Normal tissue changes (NTC) of the normal lung parenchyma are commonly seen after stereotactic single-dose radiotherapy (radiosurgery) of lung tumors. The aim of this study was to investigate the extent and dynamics of NTCs after radiosurgery. Fifty lung tumors in 49 patients were treated with radiosurgery. Follow-up CTs were anatomically matched to the treatment planning CTs, incorporating the treatment plan and enabling spatial correlation of initial radiation dose distribution and subsequent NTCs of the lung. Lung parenchyma was divided into nine areas of different radiation dose exposures (range, 6-35 Gy). Areas were investigated and compared at different time points according to the development of NTCs. Twenty-six patients developed NTCs during follow-up. The evaluation of the dependency of the extent of NTCs on the amount of radiation dose lead to a linear model for the fixed effects: Fraction of reacting volume =Intercept(T) +0.0208 * Dose ("Dose" should be given in Gy). Dose had a slope of 0.0208 (fraction of normal tissue reaction/Gy) (SE 0.000804, p < 0.0001), implying a significant correlation between dose level and the extent of NTC. For radiosurgery of lung tumors, a significant correlation of radiation dose and th...Continue Reading

References

Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LeeW J Curran
Apr 1, 1997·Chest·B MovsasC J Link
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·M V GrahamC A Perez
May 30, 2002·AJR. American Journal of Roentgenology·Titus R KoenigCraig W Stevens
Apr 22, 2004·AJR. American Journal of Roentgenology·Toshiaki TakedaAtsushi Kubo
Sep 21, 2004·Investigative Radiology·Christian PlathowPeter E Huber
Jun 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Ellen D YorkeC Clifton Ling
Jun 21, 2005·International Journal of Radiation Oncology, Biology, Physics·Vivek Mehta
Nov 14, 2006·International Journal of Radiation Oncology, Biology, Physics·Ina KyasChristian P Karger
Nov 28, 2007·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Holger HofKlaus Herfarth
Dec 7, 2007·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Matthias GuckenbergerMichael Flentje

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Citations

Aug 11, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Gilles DefraeneDirk De Ruysscher
Sep 26, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Uffe BernchouCarsten Brink
Oct 12, 2010·International Journal of Radiation Oncology, Biology, Physics·David A PalmaSuresh Senan
Feb 7, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kitty HuangDavid A Palma
May 11, 2012·Physics in Medicine and Biology·Sangkyu LeeIssam El Naqa
Apr 21, 2011·Expert Review of Anticancer Therapy·Simon S LoHiginia R Cardenes

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