PMID: 1203964Dec 18, 1975Paper

Time- and dose-dependent influence of ouabain on the ultrastructure of optic neurones

Cell and Tissue Research
H Wolburg

Abstract

The cardiac glycoside ouabain was injected into the eye-bulb of the teleost fish, Carassius carassius. Three doses of ouabain were used: 10(-4) M, 10(-5) M, 10(-6) M. The final concentrations in the vitreous body of the eye were approximately 3-10(-5) M, 3-10-6 M and 3-10-7 M, respectively. After 8 hrs, 1, 2, 4, 6 and 8 days the ultrastructural alterations of retinal ganglion cells, the optic axons near the bulb and the terminal segments in the optic tectum were studied. The high doses of ouabain induced an early necrobiosis of the cell bodies in the retina followed by degeneration in the nerve. This is characterized as a protracted form of Wallerian degeneration. The significance of the inhibition of Na+ -K+-activated ATPase at the perikaryal level for both the integrity of axonal morphology and the axonal flow is discussed.

Citations

Apr 12, 2002·Journal of Neurochemistry·Z W LiuS Kato
Jan 11, 2012·Journal of Visualized Experiments : JoVE·Ryan ThummelDavid R Hyde
Jan 29, 2010·Brain Research Bulletin·Yan LiGuo-Min Zhou
Dec 29, 2007·Developmental Neurobiology·Ryan ThummelDavid R Hyde
Nov 15, 2007·Developmental Neurobiology·Tshering SherpaDeborah L Stenkamp
Mar 30, 1976·Acta Neuropathologica·H Wolburg
Jul 1, 1988·Journal of Neurobiology·P A RaymondP K Rivlin

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