Time- and dose-related changes in the expression of substance P in salivary glands in response to fractionated irradiation

International Journal of Radiation Oncology, Biology, Physics
Y AaltoR Henriksson

Abstract

The expression of different neuropeptides in the innervation of submandibular and parotid glands of the rats was examined 2 and 5 days after initiation of radiation treatment as well as 10 and 180 days following the termination of irradiation. The irradiation was given on 2 or 5 consecutive days with daily doses of 4-8 Gy up to a total dose of 20-40 Gy. Immunohistochemical methods were used for the demonstration of substance P (SP), calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and, the rate-limiting enzyme in the catecholamine synthetic pathway, tyrosine hydroxylase (TH). The content of SP was also analyzed by the use of radioimmunoassay (RIA). In the parenchyma of both the submandibular and the parotid glands of control animals as well as after 2 days of irradiation treatment, a few nerve fibers showing SP-like immunoreactivity (LI) were observed. A marked increase in the expression of SP in the innervation of the parenchyma in both glands was observed 10 days after cessation of radiation treatment. The number of stained nerve fibers and the intensity of fluorescence in the fibers seemed to be dose dependent because the group subjected to a total dose of 40 Gy displayed a more pronounced staining intensity than...Continue Reading

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Citations

Sep 30, 1995·International Journal of Radiation Oncology, Biology, Physics·L C Stephens, K K Ang
Jan 29, 1997·Regulatory Peptides·U HöckerfeltS Forsgren
Dec 10, 1997·International Journal of Radiation Oncology, Biology, Physics·T GranforsA Widmark
Apr 9, 2008·Regulatory Peptides·Gustav AnderssonSture Forsgren
Feb 24, 2001·Annals of the New York Academy of Sciences·S ForsgrenL Franzén

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